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Now showing items 11-20 of 30
Biosimilar’s Growth in Pharmerging Markets: An Analysis of the Regulatory Environments
(University of the Western Cape, 2020)
The introduction of biosimilars to health care markets across the globe has had some success
in increasing competition and improving the cost of healthcare. While savings are important
for driving the biosimilar uptake, ...
Synthesis and evaluation of fluorescently linked polycyclic cage derivatives for application in neurodegenerative disorders
(University of the Western Cape, 2020)
Neurodegenerative diseases (ND) are chronic and progressive in nature, and
characterized by the gradual loss of neurons in various regions of the central
nervous system (CNS). ND include Alzheimer's disease (AD), Parkinson's ...
Development of rifampicin loaded in surface-modified 4.0 G PAMAM dendrimer as a novel antituberculosis pulmonary drug delivery system
(University of the Western Cape, 2020)
Introduction: Tuberculosis (TB) is a serious bacterial infections caused by the Mycobacterium Tuberculosis (MTB) organism affecting mainly the lungs. Occasionally, MTB bacilli may be transported out of the pulmonary region ...
Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
(University of the Western Cape, 2020)
Malaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are ...
Change Management in a biopharmaceutical company
(University of Western Cape, 2020)
This study aimed to review the change management implemented in a Biopharmaceutical company in Cape Town in the light of existing literature on change management theory. Three main constructs were identified: process of ...
The formulation and characterisation of corticosteroid loaded Ethosomes for topical delivery
(University of the Western Cape, 2020)
Background/Introduction: Atopic dermatitis (AD) is one of the most prevalent diseases worldwide. It is a rapidly growing field of study with several research avenues to explore its pathophysiology and to find innovative ...
The impact of Niacin on PCSK9 levels in vervet monkeys (Chlorocebus aethiops)
(University of Western Cape, 2020)
Cardiovascular diseases (CVDs) such as ischaemic heart diseases, heart failure and stroke
remain a major cause of death globally. Various deep-rooted factors influence CVD
development; these include but are not limited ...
The impact of Niacin on PCSK9 levels in vervet monkeys (Chlorocebus aethiops)
(University of the Western Cape, 2020)
Cardiovascular diseases (CVDs) such as ischaemic heart diseases, heart failure and stroke remain a major cause of death globally. Various deep-rooted factors influence CVD development; these include but are not limited to ...
Chalcone and curcumin hybrids of indole propargylamines as multifunctional neuroprotective agents
(University of the Western Cape, 2020)
Neurodegenerative disorders (NDs) are a range of chronic brain disorders that includes
amongst others motor function loss. Parkinson’s disease (PD) is one of the common NDs that
has an insidious onset and diagnosed when ...
Transparency in medicines registration decision making: A closer look at National Medicines Regulatory Authorities (NMRAs) within the Southern African Development Community (SADC) region.
(University of the Western Cape, 2020)
Medicines registration decision-making and regulatory best practice involve transparent and consistent rule making and processes with publicly available published assessment decisions and reports (Kaine, 2020). Publication ...