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Population pharmacokinetics of terizidone and cycloserine in patients with drugresistant tuberculosis
(University of the Western Cape, 2019)
Introduction: Drug-resistant tuberculosis remains a major world health problem and
one of the leading cause of death worldwide. Despite adequate adherence to antituberculosis
drugs by patients, the emergence of drug-resistance ...
Evaluation and comparison of current legal and regulatory framework for traditional medicines in five selected African countries: A move towards harmonization of regulation of traditional medicines in Africa.
(University of the Western Cape, 2019)
Background: In Africa, traditional medicine (TM) practice has been in existence since time
immemorial as the major source of pharmacotherapy. However, unlike orthodox medicines
TM policies and regulations are not formalised ...
Discovery of anti-mycobacterial natural products from South African marine algae
(University of the Western Cape, 2019)
Tuberculosis is a communicable disease which affects millions of people around the world.
Although the case reports are declining, the eradication rate of this disease is far too slow.
Natural products have played a key ...
Review of medicine registration system in Tanzania
(University of the Western Cape, 2019)
Registration of medicines is an essential function of the national medicine regulatory system
of any country. Since the start of the medicine registration system in Tanzania in early 2000s,
no systematic review has been ...
Service learning in pharmacy: Evaluation of tuberculosis screening by pharmacy students in primary health care facilities.
(University of the Western Cape, 2019)
Background: Tuberculosis (TB) is one of the arms of the so-called quadruple burden of
disease in South Africa. One of the major impediments to TB control is failure to detect the
disease, and undiagnosed cases in the ...
The availability of persons nominated for adverse drug reporting and associated challenges in Gauteng regional and district public hospitals
(University of the Western Cape, 2019)
Background and Objectives: The reporting of adverse drug reactions (ADRs) is a major public health necessity. It is estimated that only six to 10 percent of all ADRs are reported worldwide. This number is far less than the ...
Bioassay guided fractionation of Angiotensin converting enzyme inhibitor compound from Hypericum perforatum
(University of the Western Cape, 2019)
Due to the contribution of hypertension to various cardiovascular diseases, many studies are currently focused on identifying efficient bioactive compounds with antihypertensive activity and thus reducing the levels of ...
Disposal of unused medicines from households in Cape Town
(University of Western Cape, 2019)
Evidence indicates that most South African households do not dispose of unused medicines in the
manner prescribed by the medicine’s regulatory authority. This trend is not unique to South Africa,
but several developing ...
Isolation and Bioassay evaluation of Angiotensin Converting Enzyme inhibitory compounds of Centella asiatica
(University of the Western Cape, 2019)
Hypertension is by far the most common risk factor for cardiovascular disease (CVD), which has been identified as the leading cause of death worldwide and a major economic burden in developing countries. Over the years, ...
Additional regulatory review pathways can facilitate faster dossier approvals in South Africa
(University of the Western Cape, 2019)
The objective of the study was to perform a comparative review of pathways, timelines and improvements of countries with markets that the South African Health Products Authority (SAHPRA) benchmark themselves against. ...