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Risk based approach of post- approval changes in central America and Dominican republic, identifying opportunities for convergence with EMA and FDA
(University of Western Cape, 2021)
In Central American countries (Guatemala, El Salvador, Honduras, Nicaragua,
Costa Rica and Panama) and Dominican Republic (DR) the approval timelines for major changes
are described ranging from 12 to 18 months, these ...
The physicochemical characterisation, compatibility testing and solid-state form screening of terizidone - Pyridoxine combinations
(University of Western Cape, 2021)
Terizidone (TZD) is considered an essential anti-tuberculosis drug and in South
Africa it is prescribed as part of the multi-drug resistant tuberculosis (MDR-TB) treatment
regimen. From a literature study it became ...
Exploration of the training/educational background and the roles of regulatory affairs associates/officers in selected South African based pharmaceutical companies in Gauteng province
(University of Western Cape, 2021)
Regulatory Affairs (RA), within the pharmaceutical business, could be a profession that covers different registration parameters of a pharmaceutical product. This is a profession that was developed to protect the public ...
Awareness regarding non-steroidal anti-inflammatory drug-related side effects in Johannesburg, South Africa
(University of Western Cape, 2021)
Non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most commonly used medications globally, as they are highly effective and easily accessible. The NSAIDs are indicated for mild to moderate pain management. The ...
Selected antiretroviral and anti-tuberculosis drug combinations by non-covalent bonding
(University of Western Cape, 2021)
Treatment of the human immunodeficiency virus (HIV) and tuberculosis (TB) infections have become very complicated due to the advent of drug resistance. Drug combinations offer an alternative approach to reducing the emergence ...
Exploring the factors influencing the sustainability of mobile clinics for the delivery of the expanded programme on immunisation to the rural areas of the Northern Cape.
(University of Western Cape, 2021)
The Northern Cape province has not been able to achieve the 90% immunization target recommended for South Africa’s expanded programme on immunisation (EPI). The situation has been attributed to the lack of access to EPI ...
Perceptions of the pharmaceutical industry and regulators in South Africa towards registration harmonisation in the Southern African Development Community (SADC)
(University of the Western Cape, 2021)
Medicines have to be regulated in an effort to monitor their quality, safety, and efficacy. The
process of medicines registration is lengthy, costly, and document-heavy. Many countries have
limited expertise and resources ...
Pharmacological Characterization and Chemo-informatics analysis of Compounds from Leonotis leonurus.
(2021)
The central nervous system (CNS), consisting of the brain and the spinal cord, is responsible for
integrating sensory information and influencing most bodily functions . The CNS is protected from
toxic and pathogenic ...
Taste-masking of efavirenz through microencapsulation
(University of the Western Cape, 2021)
It is a well-known fact that a significant gap exists in the development of child-friendly
dosage forms, detrimentally affecting paediatric patient compliance, especially in the treatment of
debilitating diseases such ...
Venous thromboembolism risk assessment and prophylaxis in selected public sector hospitals in the Cape Town metropole
(University of the Western Cape, 2021)
Background: Venous thromboembolism (VTE) is reported to be the leading
cause of death in hospitalised patients worldwide. Thromboprophylaxis
provides a well-established and evidence-based approach to preventing VTE.
This ...