Browsing Philosophiae Doctor - PhD (Medical BioScience) by Issue Date
Now showing items 41-60 of 71
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The antifungal effect of Salvadora persica and Euclea natalensis on Candida isolates from Libyan patients with type 2 Diabetes mellitus.
(University of the Western Cape, 2018)Improved oral hygiene plays a vital role on quality of health and well-being of diabetic patients. Poor oral health leads to an increased incidence of oral diseases, particularly oral candidiasis. The emergence and global ... -
Investigating the anti-cancer activity of novel phenothiazines in glioblastoma
(University of the Western Cape, 2018)Glioblastoma multiforme (GBM) remains the most malignant of all primary adult brain tumours. It is a highly invasive and vascularized neoplasm with limited treatment options and very low survival rate. GBM tumours are ... -
Identification and characterisation of cephalosporins and carbapenem-resistant Klebsiella pneumoniae isolates from Misrata, Libya
(University of the Western Cape, 2018)Background: Extended-spectrum beta-lactamase-producing (ESBL) and carbapenemaseproducing Gram-negative bacilli showing resistance to cephalosporins and carbapenems respectively, have been reported from several countries ... -
The role of high-risk human papillomavirus in periocular cancers
(University of the Western Cape, 2018)PURPOSE: High risk human papillomavirus (HR-HPV) is well established as a causative agent of squamous cell carcinoma (SCC) of the orophaynx. HR-HPV has also been reported in periocular cancers and precancers, but controversy ... -
Aspects of the reproduction of male and female African penguins (Spheniscus demersus) with special reference to sperm biology and cryopreservation
(University of the Western Cape, 2018)In the marine environment, penguins have been described as curators and serve a critical role in ecological balance. The African penguin (Spheniscus demersus) has undergone a rapid population decline, mainly due to ... -
An analysis of the morphological and biological properties of a novel human leukocyte- and platelet- rich concentrate
(University of the Western Cape, 2018)Wound healing is a complex process that involves several overlapping and interacting biological pathways. The consequences of delayed or abnormal wound healing may result in tissue formation that has impaired function ... -
The role of high-risk human papillomavirus in periocular cancers
(University of the Western Cape, 2018)Purpose: High risk human papillomavirus (HR-HPV) is well established as a causative agent of squamous cell carcinoma (SCC) of the orophaynx. HR-HPV has also been reported in periocular cancers and precancers, but controversy ... -
Role of Rutin in 1-Mtthyl-4-Phenylpyridinium toxicity: Therapeutic implications for Parkinson's disease
(University of the Western Cape, 2018)Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. Although the etiology of PD is not ... -
Phenotypic and molecular characteristics of Methicillin-resistant Staphylococcus Aureus isolates from stored patient samples in Misurata hospitals and poultry from commercial markets, Libya
(University of the Western Cape, 2019)The emergence of virulent and drug-resistant bacterial strains such as methicillin-resistant Staphylococcus aureus (MRSA) is a global public health burden. The World Health Organization (WHO) has placed MRSA and ... -
An evaluation of cancer biomarkers in normal ovarian epithelial cells and ovarian cancer cell lines
(University of the Western Cape, 2019)Introduction: Globally, there are over 190,000 new reported cases of ovarian cancers per annum. This comprises 3% to 4% of all cancers in women. Ovarian cancer is one of the leading causes of deaths in women. Ovarian cancer ... -
The effect of maternal exposure to alcohol and nicotine on pancreas and kidney size, aorta and carotid intima thickness and visceral fat in their children.
(University of Western Cape, 2019)In utero exposure to teratogens, increasing urbanization, rapid nutritional transition from poverty to affluence, adoption of a Western-style diet and physical inactivity have contributed to the growing obesity epidemic ... -
Potential anti-melanogenic effects of selected South African plants on b16 melanoma cells
(University of the Western Cape, 2019)Dyspigmentation is one of the commonest dermatological presenting complaints from patients, particularly hyperpigmentation. Hyperpigmentation can cause dangerous psychological and emotional impact on self-perception and ... -
Protein expression and antifungal effect of fluconazole-resistant Candida species following effective in vitro treatment with K21, a novel antifungal agent
(University of Western Cape, 2019)Background: Oropharyngeal candidiasis, caused by the fungus Candida, is the most common opportunistic infection affecting the quality of life of immunocompromised patients. Fluconazole is widely used as the first line ... -
Radiation-induced leukaemia in South Africa: response of lymphocytes and cd34+ cells to different radiation qualities.
(University of the Western Cape, 2020)Epidemiological studies have highlighted that leukaemia can be considered as the most prominent malignancy after radiation exposure during childhood. The lifetime risk on radiation-induced leukaemia for a given dose is 3 ... -
Typha capensis—An electron rich resource for the synthesis of phytochemical-encapsulated gold nanoparticles through green nanotechnology
(University of the Western Cape, 2020)Typha capensis (T. capensis), commonly known as bulrush, is a medicinal plant found growing in the wetland areas of South Africa. In traditional medicine, rhizome decoctions of T. capensis are used to treat a wide variety ... -
The effects of various combinations of different Cdasses of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 and triple-negative MDA-MB 231 breast carcinoma cell lines
(University of the Western Cape, 2020)Globally, breast cancer is the most common cancer affecting women and it is predicted that in 2030 about 12 million deaths will occur with approximately 21.7 million new cases [2]. Genetic risk factors as well as race and ... -
Radiation-induced Leukaemia in South Africa: Response of lymphocytes and cd34+ cells to different radiation qualities
(University of the Western Cape, 2020)Epidemiological studies have highlighted that leukaemia can be considered as the most prominent malignancy after radiation exposure during childhood. The lifetime risk on radiation-induced leukaemia for a given dose is 3 ... -
Differential toxicity of two murine endothelial cells to ROS duress: Understanding oxidative stress-induced blood-brain barrier dysfunction
(University of the Western Cape, 2020)The blood-brain barrier (BBB) is a critical interface between the blood circulation and brain tissue which performs critical selection of circulating molecules that gain access to the brain tissue. Its unique ability to ... -
Marine invertebrate sperm: Assessment of sperm quality using computer-aided sperm analysis
(University of Western Cape, 2020) -
The impact of nanoparticles on the proteome of cultured human cells
(2021)Living organisms are constantly being exposed to nanoparticles (NPs) in the environment via air, water, soil. Routes of exposure are usually in the form of industrial, occupational exposure, as well as therapeutic ...