Browsing Philosophiae Doctor - PhD (Medical BioScience) by Issue Date
Now showing items 1-20 of 72
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The relationship between "fertilizaiton environment" and structure and physiology of selected Anuran Spermatozoa
(University of the Western Cape, 1993)The propagation of species and modes of fertilization of higher vertebrates are aspects which have been extensively researched. Studies on the spermatology of lower vertebrates have not received the same attention. Anurans ... -
Fatty acids as cancer preventive tools in the dietary modulation of altered lipid profiles associated with hepatocarcinogenesis
(University of the Western Cape, 2005)This thesis consists of a brief description on cancer, carcinogenesis, the changes in the type and level of dietary fat available in our diets over time and association with the development of certain diseases. The main ... -
Apoptotic markers in ejaculated human spermatozoa
(University of the Western Cape, 2005)The role of male germ cell death in spermatogenesis is an important one as it removes dysfunctional or genetically damaged germ cells and is necessary to maintain an optimal germ cell to Sertoli cell ratio. The formation ... -
The influence of maternal nicotine exposure on selected glycolytic and cytochrome P450 enzymes in developing neonatal rat lung
(University of the Western Cape, 2005)The structural and functional integrity of a developing and maturing fetal and neonatal lung is critically dependent on carbohydrate metabolism. The energy derived from carbohydrate metabolism is utilized during the processed ... -
An investigation into the effect of maternal exposure to nicotine and copper on neonatal lung development
(University of the Western Cape, 2006)In the 20th century, where tobacco smoking continues to be the leading preventable cause of death, an alarming number of people continue to smoke, despite awareness of the implications of exposure for themselves and those ... -
Synergistic effects of mixtures of fungicides and medicinal plant extracts against Botrytis cinerea
(University of the Western Cape, 2008)We hypothesize that South African medicinal plants contain compounds that can act in synergism with synthetic antifungal compounds. Four fungicides - Sporekill™, Rovral™, Terminator™ and Teldor™ at doses 0.1, 0.2, 0.4 and ... -
The development and implementation of biomarker assays for estrogenic endocrine disruptors
(University of the Western Cape, 2008)Endocrine disrupting chemicals (EDCs) are compounds found in the environment that have the potential to disrupt normal endocrine function. Estrogenic EDCs (e-EDCs) is a subclass of EDCs and is defined as substances ... -
Synergistic effects of mixtures of fungicides and medicinal plant extracts against Botrytis cinerea
(University of the Western Cape, 2008)We hypothesize that South African medicinal plants contain compounds that can act in synergism with synthetic antifungal compounds. Four fungicides - Sporekill™, Rovral™, Terminator™ and Teldor™ at doses 0.1, 0.2, 0.4 and ... -
Synergistic effects of mixtures of fungicides and medicinal plant extracts against botrytis cinerea
(University of the Western Cape, 2008)We hypothesize that South African medicinal plants contain compounds that can act in synergism with synthetic antifungal compounds. Four fungicides - Sporekill™, Rovral™, Terminator™ and Teldor™ at doses 0.1, 0.2, 0.4 and ... -
Phylogeography and speciation in the genus arthroleptella
(2009)Moss frogs are restricted to permanently moist terrestrial habitats in the south-western Cape Fold Mountains. There is a very close association between Arthroleptella distribution and Table Mountain Sandstone. Suitable ... -
The effect of nicotine and prostaglandin A2 on the lung cancer cell line NCI-H157
(2009)Lung cancer is the most common fatal cancer in terms of both incidence and mortality in the world. The most important cause of lung cancer is exposure to tobacco smoke through active or passive smoking. Nicotine which is ... -
The screening of phyto-pesticides for potential adverse effects on human health
(University of the Western Cape, 2010)Pesticides are designed to control or eliminate pests such as insects, rodents, weeds, bacteria, and fungi. They are used at a global scale for agricultural produce. Although pesticides play a significant role in increasing ... -
The implementation of in vitro assays to screen environmental samples for male reproductive toxicity
(University of the Western Cape, 2010)Endocrine disrupting compounds (EDCs) are exogenous compounds/chemicals which interfere with, or have adverse effects on the production, distribution and function of natural hormones, thereby affecting normal endocrine ... -
''A molecular investigation of the prevalence of suspected periodontopathogens and their association with preterm birth.''
(University of the Western Cape, 2010)More than 20 million infants in the world (15.5 % of all births) are born with low birth weight. Ninety-five oZ of them are in developing countries. Oral colonization of Gramnegative anaerobes has been implicated as a risk ... -
A molecular investigation of the prevalence of suspected periodontopathogens and their association with preterm birth
(University of the Western Cape, 2010)More than 20 million infants in the world (15.5 % of all births) are born with low birth weight. Ninety-five % of them are in developing countries. oral colonization of gram-negative anaerobes has been implicated as a risk ... -
The screening of phyto-pesticides for potential adverse effects on human health
(University of the Western Cape, 2010)Pesticides are designed to control or eliminate pests such as insects, rodents, weeds, bacteria, and fungi. They are used at a global scale for agricultural produce. Although pesticides playa significant role in increasing ... -
Structural and functional characterization of human DDX5 and its interaction with NS5B of hepatitis C virus
(University of the Western Cape, 2011)Hepatitis C was first recognized as a transfusion-associated liver disease not caused by hepatitis A or hepatitis B virus after serological tests were developed to screen for their presence in the blood. The infectious ... -
Sperm mitochondria: species specificity and relationships to sperm morphometric features and sperm function in selected mammalian species
(University of the Western Cape, 2011)Numerous studies on mammalian spermatozoa have reported large variations in the dimensions of the main sperm structural components, namely the head, midpiece and flagellum. These variations in sperm architecture are believed ... -
Assessment of the biological quality of raw and treated effluents from three sewage treatment plants in the Western Cape, South Africa
(University of the Western Cape, 2011)The aim of this study was to compare the water quality of raw wastewater and treated sewage effluents from three different sewage treatment plants in the Western Cape, South Africa. The treatment plants investigated are ... -
The effects of artificial and natural sweeteners on various physiological systems
(University of the Western Cape, 2011)This study aimed to investigate the effects of commercially available natural (sugar cane molasses, white sugar and brown sugar) and artificial (Canderel, Equal, Natreen, Sweetex, Splenda and Swheet) sweeteners on various ...
