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Design and synthesis of new scaffolds as antiproliferative agents and potential hsp90 inhibitors
(University of Western Cape, 2020)
Natural products have been an important source of drugs and novel lead compounds in drug
discovery. Their unique scaffolds have led to the synthesis of derivatives that continue to give rise
to medicinally relevant agents. ...
Novel norbornane derivatives as potential neuroprotective agents
(University of Western Cape, 2020)
Neurodegenerative disorders are characterised by progressive loss of the brain’s physiological
functions as a result of gradual degeneration of neurons in the central nervous system. Even
though they are classified as ...
Selected antiretroviral and anti-tuberculosis drug combinations by non-covalent bonding
(University of Western Cape, 2021)
Treatment of the human immunodeficiency virus (HIV) and tuberculosis (TB) infections have become very complicated due to the advent of drug resistance. Drug combinations offer an alternative approach to reducing the emergence ...
Development of rifampicin loaded in surface-modified 4.0 G PAMAM dendrimer as a novel antituberculosis pulmonary drug delivery system
(University of the Western Cape, 2020)
Introduction: Tuberculosis (TB) is a serious bacterial infections caused by the Mycobacterium Tuberculosis (MTB) organism affecting mainly the lungs. Occasionally, MTB bacilli may be transported out of the pulmonary region ...
Discovery of antibacterial lead compounds from marine organisms
(University of the Western Cape, 2020)
Marine organisms including algae and bacteria are known to produce chemically diverse secondary metabolites for survival purposes in the marine environment. Scientists have identified some of these natural products as ...
Pharmacological Characterization and Chemo-informatics analysis of Compounds from Leonotis leonurus.
(2021)
The central nervous system (CNS), consisting of the brain and the spinal cord, is responsible for
integrating sensory information and influencing most bodily functions . The CNS is protected from
toxic and pathogenic ...
Pharmacological characterization and chemo-informatics analysis of compounds from leonotis leonurus
(University of Western Cape, 2021)
The central nervous system (CNS), consisting of the brain and the spinal cord, is responsible for
integrating sensory information and influencing most bodily functions . The CNS is protected from
toxic and pathogenic ...
An exploratory study of the problem of training and skills development in the public health sector: The case of two district hospitals in the Limpopo province
(University of the Western Cape, 2022)
Public health sectors across the globe are usually faced with challenges of adopting creative
ways to improve performance and service delivery in the form of investing in employee skills
development and training. During ...
The development, implementation and evaluation of an integrated framework for undergraduate pharmacy education in maternal and child health at the University of the Western Cape
(University of the Western Cape, 2022)
The high rate of maternal and child mortality is a global health concern. Nationally, it is one of South Africa’s quadruple disease burdens. The Sustainable Development Goal 3, 2030 targets related to maternal and child ...
Factors affecting the pharmacokinetics of vancomycin in children admitted to the intensive care unit (icu) of the Red Cross War Memorial Children's Hospital (RCWMCH).
(University of the Western Cape, 2023)
Vancomycin is a glycopeptide antibiotic that inhibits bacterial cell wall synthesis by binding to the D-alanyl-D-alanine terminal end of cell wall precursor units preventing the elongation and cross-linkage of the ...