Library Portal | UWC Portal | National ETDs | Global ETDs
    • Login
    Contact Us | About Us | FAQs | Login
    View Item 
    •   ETD Home
    • Faculty of Natural Science
    • Department of Medical BioSciences
    • Magister Scientiae - MSc (Medical BioSciences)
    • View Item
    •   ETD Home
    • Faculty of Natural Science
    • Department of Medical BioSciences
    • Magister Scientiae - MSc (Medical BioSciences)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The effects of selective inhibitors of N-Glycosylation and Endoplasmic Reticulum stress inducers on Neuroblastoma cell proliferation and Apoptosis

    Thumbnail
    View/Open
    824-1527-1-RV.pdf (13.57Mb)
    Date
    2017
    Author
    Eshiak, Ebtehal Elkamel M.
    Metadata
    Show full item record
    Abstract
    Among all childhood cancers diagnosed, neuroblastoma (NB) is the most prevalent during infancy. In patients younger than 15 years, it accounts for more than 7% of malignancies and about 15% of all paediatric mortalities. A family history of NB is considered a genetic predisposition and risk factor. In 1-2% of inherited cases, the molecular causative factors linked to the disease are germline mutations, including anaplastic lymphoma kinase (ALK, gain of function), PHOX2B (loss of function) and MYCN (gain of function). NB differs from most solid tumours because of its heterogeneity in both pathobiologic and clinical behaviour, ranging from spontaneous regression to highly-aggressive metastatic disease resistant to conventional and investigational anticancer drugs. Hence, NB embodies a spectrum of disease.
    URI
    http://hdl.handle.net/11394/6105
    Collections
    • Magister Scientiae - MSc (Medical BioSciences)

    DSpace 6.3 | Ubuntu | Copyright © University of the Western Cape
    Contact Us | Send Feedback
    Theme by 
    @mire NV
     

     

    Browse

    All of RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    Statistics

    View Usage Statistics

    DSpace 6.3 | Ubuntu | Copyright © University of the Western Cape
    Contact Us | Send Feedback
    Theme by 
    @mire NV