Browsing Faculty of Natural Science by Title
Now showing items 1411-1430 of 2565
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Investigation of protein-metal ion and protein-protein interactions using mass spectrometry and nuclear magnetic spectroscopy
(University of Western Cape, 2014)Protein-protein interaction networks provide a global picture of cellular function and biological processes. Some proteins act as hub proteins, highly connected to others, whereas some others have few interactions. The ... -
Investigation of protein-protein interactions involving retinoblastoma binding protein 6 using immunoprecipitation and nuclear magnetic resonance spectroscopy
(University of Western Cape, 2019)Retinoblastoma Binding Protein 6 (RBBP6) is a 200 KDa multi-domain protein that has been shown to play a role in mRNA processing, cell cycle arrest and apoptosis. RBBP6 interacts with tumour suppressor proteins such as ... -
Investigation of protein-protein interactions involving Retinoblastoma Binding Protein 6 using immunoprecipitation and Nuclear Magnetic Resonance Spectroscopy
(University of the Western Cape, 2019)Retinoblastoma Binding Protein 6 (RBBP6) is a 200 KDa multi-domain protein that has been shown to play a role in mRNA processing, cell cycle arrest and apoptosis. RBBP6 interacts with tumour suppressor proteins such as ... -
Investigation of socio-demographic, clinical and genetic factors associated with blood pressure and glycaemic control among indigenous South African adult patients
(University of the Western Cape, 2021)Achieving blood pressure and glycaemic treatment targets remain a major public health challenge in individuals with hypertension and diabetes mellitus (DM). This research project was, therefore, designed to investigate the ... -
Investigation of some possible mechanisms involved in the anticonvulsant activity of Tulbaghia violacea harv
(University of the Western Cape, 2015)Even though Tulbaghia violacea has been used to treat and manage epilepsy in South Africa by traditional medicine practitioners, no evidence in any literature has shown any scientific scrutiny of the effectiveness of the ... -
Investigation of South African estuarine microbial species and genome diversity
(University of the Western Cape, 2006)A study of the microbial diversity in sediments of the Great Berg River estuary is carried out using modern molecular phylogenetic methods. The aim of this study was to determine the effect of (pollution by) the effluents ... -
Investigation of stains existing on fossil samples from the sterkfonfein archeaologica sites
(University of the Western Cape, 2006)It is known that fossilized bone samples excavated from the Sterkfontein archaeological sites have prominent brown stains on their surfaces. Their existence has been postulated by researchers from Transvaal museum to be ... -
Investigation of suitable microencapsulation techniques in the preformulation of selected antiretroviral drugs
(University of the Western Cape, 2022)Background: The use of antiretroviral drugs (ARVDs) in the treatment of HIV/AIDS have been promising and effective especially amongst adults as it suppresses the viral load, thereby improving the life expectancy of HIV ... -
Investigation of telecommunication recommender systems for curated post-paid products
(University of the Western Cape, 2023)Telecommunication recommender systems -
Investigation of ternary catalysts as anode catalysts for direct methanol fuel cell
(University of the Western Cape, 2023)This chapter reports on various catalyst synthesis methods (impregnation, polyol, modified polyol and microwave-assisted modified polyol methods) to determine which method would result in the most electrochemically active ... -
Investigation of the acoustic impedance variations of the upper shallow marine sandstone reservoirs in the Bredasdorp basin, offshore South Africa
(University of the Western Cape, 2019)Investigation of the acoustic impedance variations in the upper shallow marine sandstone reservoirs was extensively studied from 10 selected wells, namely: F-O1, F-O2, E-M4, E-CN1, E-G1, E-W1, F-A10, F-A11, F-A13, and F-L1 ... -
Investigation of the anti-obesity effects of citrate-capped gold nanoparticles on 3T3-L1 cells and their genetic profiling
(University of the Western Cape, 2023)The incidence and prevalence of obesity and its related diseases has nearly tripled and is increasing at an alarming rate worldwide. Several modern methods for the management and treatment of obesity are available, with ... -
Investigation of the antidiabetic activity of Cnicusbenedictus L. in rats
(University of the Western Cape, 2016)Diabetes Mellitus, one of the major diseases affecting human population all over the world has caused significant morbidity and mortality. The management of this condition has raised the demand of safe and cost effective ... -
Investigation of the auto-ubiquitination and ubiquitination potentials of Retinoblastoma binding protein 6 and its binding to p53
(University of Western Cape, 2019)Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa human protein known to play an essential role in mRNA 3’-end processing, as well as functioning as an E3 ligase to catalyze ubiquitination and suppression of p53 and ... -
An investigation of the best-practices for implementing an Ecommerce software engineering project comparing two common methodologies, viz. Agile and Traditional.
(University of the Western Cape, 2020)In a world where technology is advancing at a very rapid pace, global competition has significantly increased, and this is putting pressure on software companies to produce quality software. It has therefore become critically ... -
An investigation of the effects of donor age on some haematological characteristics of the Wistar rat (Rattus Norwegicus)
(University of the Western Cape, 1986)Knowledge of haematological 'normdata', of experimental animals, and the biological variables that affect it is essential in order to recognise variations from the normal. In addition, the haemopoietic system may be ... -
Investigation of the in vitro antidiabetic and neuroprotective effects of selected Helichrysum species against high monosaccharide-induced toxicity
(University of the Western Cape, 2022)Chronic hyperglycaemia (glucotoxicity), a common complication in diabetes mellitus (DM), is known to cause cognitive decline in some of these patients, often affecting their overall quality of life. Some medicinal plants ... -
Investigation of the in vitro bioavailability of luteolin from modified preparations of Artemisia afra
(University of the Western Cape, 2014)Artemisia afra (A. afra) is traditionally used for a variety of ailments and contain flavonoids e.g. luteolin which may contribute to some of its activity. It is generally administered as a tea or decoction, and such liquid ... -
Investigation of the interaction of ceramide and acyl-coenzyme A with the mitochondrial associated protein, endozepine, using heteronuclear NMR
(University of the Western Cape, 2005)Endozepine is an alternative name for the testis-specific isoform of the acyl-CoA binding protein (t-ACBP). Acyl-CoA binding proteins form a highly conserved family of proteins, which bind long chain fatty acid esters with ... -
Investigation of the interactions of retinoblastoma binding protein-6 with transcription factors p53 and Y-Box Binding Protein-1
(2011)Retinoblastoma Binding Protein 6 (RBBP6) is a 250 kDa multi-domain protein that has been implicated in diverse cellular processes including apoptosis, mRNA processing and cell cycle regulation. Many of these functions are ...