Browsing Faculty of Natural Science by Issue Date
Now showing items 1-20 of 1648
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Synergistic use of promoter prediction algorithms: a choice of small training dataset?
(University of the Western Cape, 2000)Promoter detection, especially in prokaryotes, has always been an uphill task and may remain so, because of the many varieties of sigma factors employed by various organisms in transcription. The situation is made more ... -
New algorithms for EST clustering
(University of the Western Cape, 2000)Summary: Expressed sequence tag database is a rich and fast growing source of data for gene expression analysis and drug discovery. Clustering of raw EST data is a necessary step for further analysis and one of the most ... -
Oxidative fixation of dinitrogen by photocatalysis
(University of Western Cape, 2000)The heterogeneous photocatalytic oxidation of dinitrogen to nitrate, NO3 and/or nitrite, no2 using peroxy species of titanium (IV) in aqueous suspensions has been investigated. The photocatalysts used were titanium peroxide ... -
Novel genomic approaches for the identification of virulence genes and drug targets in pathogenic bacteria
(University of the Western Cape, 2001)While the many completely sequenced genomes of bacterial pathogens contain all the determinants of the host-pathogen interaction, and also every possible drug target and recombinant vaccine candidate, computational tools ... -
Generation of a human gene index and its application to disease candidacy
(University of the Western Cape, 2001)With easy access to technology to generate expressed sequence tags (ESTs), several groups have sequenced from thousands to several thousands of ESTs. These ESTs benefit from consolidation and organization to deliver ... -
Parameters affecting the production of fumonisin B1 by fusarium verticillioides in culture
(University of the Western Cape, 2001)Fi1sarium verticillioides is a very important mycotoxin-produeing fungus associated with maize. Fverticillioides produces a group of mycotoxins known as fumonisins under suitable environmental conditions. A series of studies ... -
Low detection of exon skipping in mouse genes orthologous to human genes on chromosome 22
(University of the Western Cape, 2002)Alternative RNA splicing is one of the leading mechanisms contributing towards transcript and protein diversity. Several alternative splicing surveys have confirmed the frequent occurrence of exon skipping in human genes. ... -
HIV subtype C diversity: analysis of the relationship of sequence diversity to proposed epitope locations
(University of the Western Cape, 2002)Southern Africa is facing one of the most serious HIV epidemics. This project contributes to the HIVNET, Network for Prevention Trials cohort for vaccine development. HIVÂ’s biology and rapid mutation rate have made vaccine ... -
Chytridiomycosis in amphibian populations in the Western Cape, South Africa
(University of the Western Cape, 2002)There have been many cases reported of amphibian populations declining. These are often due to anthropogenic factors such as habitat destruction and pollution. However, some eclines have not had an obvious cause and many ... -
Molecular detection and genetic manipulation of the Black Queen Cell Virus
(University of the Western Cape, 2002)The South African isolate of the Black Queen-Cell Virus (BQCV), a honeybee virus, was previously found to have an 8550 nucleotide genome excluding the poly(A) tail. Its genome contained two ORFs, a 5'-proximal ORF encoding ... -
Expression and purification of the novel protein domain DWNN
(University of the Western Cape, 2002)Proteins play an important role in cells, as the morphology, function and activities of the cell depend on the proteins they express. The key to understanding how different proteins function lies in an understanding of the ... -
Policy based network management of legacy network elements in next generation networks for voice services
(University of the Western Cape, 2002)Telecommunication companies, service providers and large companies are now adapting converged multi-service Next Generation Networks (NGNs). Network management is shifting from managing Network Elements (NE) to managing ... -
The extraction, purification and evaluation of compounds from the leaves of Leonotis Leonorus for anticonvulsant activity
(University of the Western Cape, 2002)The aim of this study is to isolate and evaluate the anticonvulsant components from the leaves of Leonotis leonorus (L) R.aR. and to see if there is any change in activity with the origin of the plant material and I or the ... -
Chytridiomycosis in amphibian populations in the Western Cape, South Africa
(University of the Western Cape, 2002)There have been many cases reported of amphibian populations declining. These are often due to anthropogenic factors such as habitat destruction and pollution. However, some declines have not had an obvious cause and many ... -
The development and application of informatics-based systems for the analysis of the human transcriptome
(University of the Western Cape, 2003)Despite the fact that the sequence of the human genome is now complete it has become clear that the elucidation of the transcriptome is more complicated than previously expected. There is mounting evidence for unexpected ... -
An investigation into the synthesis, characterisation and some applications of novel metal-containing polymers and dendrimers of transition metals
(University of the Western Cape, 2003)metal-containing complexes, that exhibit enhanced chemical and physical properties. This thesis describes the synthesis of new metal-containing linear polymers and dendritic molecules. Chapter 1 presents an overview of ... -
The application of magnetic resonance and computed tomography imaging in the diagnosis and management of maxillofacial tumours
(University of Western Cape, 2004)The Application of Magnetic Resonance (MRI) and Computed Tomography Imaging (CT) in the Diagnosis and Management of Maxillofacial Tumours. For decades maxillofacial surgeons over the world have been frustrated by the high ... -
The genease activity of mung bean nuclease: fact or fiction?
(University of the Western Cape, 2004)The action of Mung Bean Nuclease (MBN) on DNA makes it possible to clone intact gene fragments from genes of the malaria parasite, Plasmodium. This “genease” activity has provided a foundation for further ... -
Assessment of genome visualization tools relevant to HIV genome research: development of a genome browser prototype
(University of the Western Cape, 2004)Over the past two decades of HIV research, effective vaccine candidates have been elusive. Traditionally viral research has been characterized by a gene -by-gene approach, but in the light of the availability of complete ... -
Determination of natural radioactivity concentrations in soil: a comparative study of Windows and Full Spectrum Analysis
(University of the Western Cape, 2004)In this study, two methods of analysing activity concentrations of natural radionuclides (U, Th and K) in soil are critically compared. These are the Window Analysis (WA) and Full Spectrum Analysis (FSA). In the usual WA ...
