Browsing Faculty of Natural Science by Author "Ekpo, Okobi"
Now showing items 1-13 of 13
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The development of functionalized metallic nanoparticles for the treatment of brain cancer
Fipaza, Vincent Lukhanyiso (University of the Western Cape, 2019)Cancers of the nervous system often result from abnormal and uncontrolled growth of cells in nervous tissue. Glioblastoma Multiforme (GBM) and neuroblastoma (NB) are among the most common nervous system-associated cancers ... -
The development of targeting nanosystems for the treatment of glioblastoma and neuroblastoma tumours
Boltman, Taahirah (University of the Western Cape, 2022)Chlorotoxin (CTX) peptide selectively targets glioblastoma multiforme (GB) and neuroblastoma (NB) and has excellent blood-brain barrier permeability. Therefore, CTX is a promising targeting molecule for nanoparticle (NP) ... -
Evaluating the neuroprotective effects of fermented rooibos herbal tea in Wistar rats exposed to bisphenol-A during gestation and lactation
Gamoudi, Bushra Khalifa (University of the Western Cape, 2019)Exposure to endocrine-disrupting chemicals as bisphenol A (BPA) during gestation and early postnatal life is known to disrupt normal developmental processes and alter the body’s endocrine system leading to deleterious ... -
An evaluation of cancer biomarkers in normal ovarian epithelial cells and ovarian cancer cell lines
Fruka, Tayra (University of the Western Cape, 2019)Introduction: Globally, there are over 190,000 new reported cases of ovarian cancers per annum. This comprises 3% to 4% of all cancers in women. Ovarian cancer is one of the leading causes of deaths in women. Ovarian cancer ... -
In vitro neuroprotective effects of boophone disticha, brunsvigia bosmaniae and strumaria truncata extracts in sh-sy5y cells.
Kangwa, Tusekile Sarah (University of Western Cape, 2021)Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease, is one of the leading disability disorders with about 10 million people affected worldwide. The pathological hallmarks ... -
In vitro neuroprotective potential of phyllanthin in MPP+- induced toxicity in SH-SY5Y neuroblastoma cells
Delport, Joshua (University of the Western Cape, 2023)Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s disease, with an estimated 9 million people projected to be affected worldwide by the year 2030. PD is associated ... -
Investigating the anti-cancer activity of novel phenothiazines in glioblastoma
Omoruyi, Sylvester Ifeanyi (University of the Western Cape, 2018)Glioblastoma multiforme (GBM) remains the most malignant of all primary adult brain tumours. It is a highly invasive and vascularized neoplasm with limited treatment options and very low survival rate. GBM tumours are ... -
Liposomal drug delivery to brain cancer cells
Boltman, Taahirah (University of the Western Cape, 2015)Neuroblastomas (NBs) are the most common solid extra-cranial tumours diagnosed in childhood and characterized by a high risk of tumour relapse. Like in other tumour types, there are major concerns about the specificity and ... -
The potential neuroprotective effects of two South African plant extracts in hydrogen peroxide-induced neuronal toxicity
Gier, Megan Loran (University of the Western Cape, 2018)Background: Oxidative stress induced by reactive oxygen species has been strongly associated with many neurodegenerative diseases (NDDs) and many medicinal plant-derived products have been reported to exert potent antioxidant ... -
Radioprotective effects of rooibos herbal tea on the developing central nervous system of wistar rats
Alrtemi, Milod M Ahmed (University of the Western Cape, 2018)Background: Early postnatal radiation exposure from environmental, diagnostic or therapeutic sources is potentially deleterious to the developing nervous system resulting in oxidative stress, structural damage, altered ... -
Role of Rutin in 1-Mtthyl-4-Phenylpyridinium toxicity: Therapeutic implications for Parkinson's disease
Enogieru, Adaze Bijou (University of the Western Cape, 2018)Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. Although the etiology of PD is not ... -
Synthesis, characterization and anticancer effects of quantum dots in neuroblastoma and glioblastoma cell lines
Lasher, Sashca Yosima (University of the Western Cape, 2018)Introduction: Nanoparticles (NPs) are gaining increased popularity for cancer treatment, especially the multifunctional nanoparticles like Quantum dots (QDs) which have a wide range of applications in nanotheranostics, ... -
The effects of selective inhibitors of n-glycosylation and endoplasmic reticulum stress inducers on the expression of neuroblastoma drug resistance
Husein, Wejdan A.B. Mahmud (University of the Western Cape, 2017)Neuroblastoma (NB) represents 8-10% of all childhood tumours and accounts for approximately 15% of all cancer-related deaths in the paediatric population. Approximately half of newly diagnosed children with this tumour ...