Browsing Faculty of Natural Science by Author "Gamieldien, Junaid"
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Aberrations in the Retinoblastoma susceptibility gene in tumours from South Africa oesophageal cancer patients
Gamieldien, Junaid (University of the Western Cape, 1996)Little is known about the genetic events occurring in oesophageal cancer and very few studies have been undertaken to analyse oesophageal tumours from South African patients in this regard. Inactivation of numerous tumour ... -
Computational analysis of multilevel omics data for the elucidation of molecular mechanisms of cancer
Fatai, Azeez Ayomide (University of the Western Cape, 2015)Cancer is a group of diseases that arises from irreversible genomic and epigenomic alterations that result in unrestrained proliferation of abnormal cells. Detailed understanding of the molecular mechanisms underlying a ... -
Computational genomics approaches for kidney diseases in Africa
Mapiye, Darlington Shingirirai (University of the Western Cape, 2015)End stage renal disease (ESRD), a more severe form of kidney disease, is considered to be a complex trait that may involve multiple processes which work together on a background of a significant genetic susceptibility. ... -
Development of a simple artificial intelligence method to accurately subtype breast cancers based on gene expression barcodes
Esterhuysen, Fanechka Naomi (University of the Western Cape, 2018)INTRODUCTION: Breast cancer is a highly heterogeneous disease. The complexity of achieving an accurate diagnosis and an effective treatment regimen lies within this heterogeneity. Subtypes of the disease are not simply ... -
Genome assembly of next-generation sequencing data for the Oryx bacillus : species of the Mycobacterium tuberculosis complex
Direko, Mmakamohelo (University of the Western Cape, 2011)Next generation sequencing (NGS) technology platforms have accelerated ability to produce completed genome assemblies. Recently, collaborators at Tygerberg Medical School outsourced the sequencing of Oryx bacillus, a ... -
Identification of potential biomarkers in lung cancer as possible diagnostic agents using bioinformatics and molecular approaches
Ahmed, Firdous (University of the Western Cape, 2015)Lung cancer remains the leading cause of cancer deaths worldwide, with the majority of cases attributed to non-small cell lung carcinomas. At the time of diagnosis, a large percentage of patients present with advanced stage ... -
Integrating regulatory and methylome data for the discovery of clear cell Renal Cell Carcinoma (ccRCC) variants
Calvert-Joshua, Tracey (University of the Western Cape, 2015)Kidney cancers, of which clear cell renal cell carcinoma comprises an estimated 70%, have been placed amongst the top ten most common cancers in both males and females. With a mortality rate that exceeds 40%, kidney cancer ... -
“An investigation into the MicroRNA-gene interactions involved in the pathogenesis of systemic lupus erythematosus”
Pitts, Stephanie Julia (University of the Western Cape, 2015)Systemic lupus erythematosus is a chronic, inflammatory disease characterised by the production of autoantibodies which target particularly the nuclear components of multiple cell types throughout the body. MicroRNA’s have ... -
Massively-Parallel Computational Identification of Novel Broad Spectrum Antivirals to Combat Coronavirus Infection
Berry, Michael (University of the Western Cape, 2015)Given the significant disease burden caused by human coronaviruses, the discovery of an effective antiviral strategy is paramount, however there is still no effective therapy to combat infection. This thesis details the ... -
Normalization and statistical methods for crossplatform expression array analysis
Mapiye, Darlington S (University of the Western Cape, 2012)A large volume of gene expression data exists in public repositories like the NCBI’s Gene Expression Omnibus (GEO) and the EBI’s ArrayExpress and a significant opportunity to re-use data in various combinations for novel ... -
Novel genomic approaches for the identification of virulence genes and drug targets in pathogenic bacteria
Gamieldien, Junaid (University of the Western Cape, 2001)While the many completely sequenced genomes of bacterial pathogens contain all the determinants of the host-pathogen interaction, and also every possible drug target and recombinant vaccine candidate, computational tools ...