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Identification of insertion-induced enhancers linked to gene drivers within non-coding DNA using a pipeline for diffuse large b-cell lymphoma H3K27ac ChIP-seq data
(University of the Western Cape, 2022)
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) and incorporates a diverse range of illnesses with varying biology, clinical manifestations, and therapeutic responses. Functional ...
Food resources available to juvenile fish (particularly rhabdosargus holubi) in seagrass beds of the swartkops etuary
(University of the Western Cape, 2023)
Estuarine habitats are critical nursery areas for many species of marine fishes during their early life stages in terms of food availability and structural complexity, which increases survival and growth rates. The Cape ...
Microscopic analysis of In vitro and In vivo effects of functionalized gold nanoparticles on the liver, kidney, spleen, heart and pancreas of male wistar rats
(University of the Western Cape, 2022)
Nanotechnology represents a promising knowledge based platform that can solve human needs and ailments, especially in cases like cancers, diabetes, antibiotic drug resistances etc. Many metallic nanoparticles are being ...
Biological and enzymatic activity of actinobacteria associated with aloe ferox
(University of the Western Cape, 2023)
Antimicrobial resistance is a global crisis that has been on the rise for decades, threatening the health and safety of many nations. This highlights the need to discover novel antimicrobial compounds to combat already ...
Synthesis of bimetallic immiscible alloy nanoparticles through green and gamma radiolysis approaches for environmental remediation applications
(University of the Western Cape, 2022)
The synthesis of bimetallic immiscible alloy nanoparticles (NPs) using versatile routes, is a major concern since physio-chemical methods are not environmentally benign. Breaking down the immiscibility would generate NPs ...
Next generation sequencing approaches for novel gene discovery in South African Parkinson’s disease families
(University of the Western Cape, 2022)
In the last decade, next-generation sequencing (NGS) approaches have revolutionised
the study of human genomics, particularly aiding the understanding of genetic diseases. Parkinson’s
disease (PD) is a complex neurodegenerative ...
Development of an operon detection algorithm to analyze gene regulation in drug resistant Mycobacterium tuberculosis
(University of the Western Cape, 2022)
In prokaryotes, operon structures often form to allow microorganisms to respond rapidly and efficiently to changing environmental conditions. Operons are sets of neighbouring genes which are co-regulated and co-transcribed. ...
Using CRISPR/Cas9 to construct consolidated bioprocessing strains from natural isolates of Saccharomyces cerevisiae
(University of the Western Cape, 2022)
Saccharomyces cerevisiae has gained much attention as a host for cellulosic bioethanol production using consolidated bioprocessing (CBP) methodologies, due to its high ethanol producing titres, heterologous protein producing ...
Synthesis and evaluation of metformin derivatives for anti-diabetes
(University of the Western Cape, 2022)
Type 2 diabetes mellitus (T2DM) is a significant public health crisis and is placed amongst the top ten leading causes of death worldwide. Metformin is the first-line drug used to treat T2DM, which is mainly attributed to ...
Investigation of common deficiencies observed in scientific assessments and the implementation of a new robust review pathway, the risk-based assessment approach, by the South African Health Regulatory Authority, SAHPRA
(University of the Western Cape, 2022)
The main objective of this study is to improve patient access to medicines. The research is two-fold, the
first component promotes transparency between the South African Health Products Regulatory
Authority (SAHPRA), ...