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Cloning and characterization of the human coronavirus NL63 nucleocapsid protein
(University of the Western Cape, 2011)
The human coronavirus NL63 was discovered in 2004 by a team of researchers in Amsterdam. Since its discovery it has been shown to have worldwide spread and affects mainly children, aged 0-5 years old, the immunocompromised ...
Massively-Parallel Computational Identification of Novel Broad Spectrum Antivirals to Combat Coronavirus Infection
(University of the Western Cape, 2015)
Given the significant disease burden caused by human coronaviruses, the discovery of an effective antiviral strategy is paramount, however there is still no effective therapy to combat infection. This thesis details the ...