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Now showing items 11-20 of 23
The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 breast carcinoma cell line
(University of the Western Cape, 2014)
This study investigated the effects of TKIs on the growth and proliferation of MCF-7 breast carcinoma cells in culture. MCF-7 cells were exposed to different concentrations of TKIs alone and in combination with each other. ...
Biochemical investigation of anti-cancer activity of Tulbaghia violacea
(UWC, 2012)
Natural products have been a source of many pharmaceutical drugs and a number of drugs that are currently used in the treatment of cancer are derivatives of compounds originally isolated from natural products. There is ...
Effect of Eurycoma longifolia (Tongkat Ali) on the prostate cancer cell line LNCaP
(2013)
Eurycoma Longfolia Jack, also known as Tongkat Ali (TA) is a tropical plant
belonging to the family of Simaroubaceae is widely distributed in South East Asian countries. The extracts of TA have been proven to have ...
Polycyclic propargylamine derivatives as multifunctional neuroprotective agents
(University of the Western Cape, 2018)
The abnormal death of neurons in the central nervous system of individuals suffering from neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis, ...
Peptide functionalised gold nanorods for the selective eradication of target cells using photothermal therapy
(University of the Western Cape, 2019)
Cancer is one of the leading causes of death, worldwide. Mortality tolls are estimated to reach approximately 13.1 million in 2030. These statistics suggest that current therapeutic strategies are not effective. This is ...
Development of nanotechnology-based therapeutic approaches to treat HIV
(University of the Western Cape, 2012)
The rapidly expanding field of nanotechnology has been the focus of many biologists with regard to drug delivery. The ability of nanoparticles to enter cellular compartments makes it possible to explore specific treatment ...
The identification of novel regulatory elements in the promoters of heat shock response genes
(University of the Western Cape, 2010)
The main objective of this study was to investigate promoter sequences of putative HSR genes for the presence of unique regulatory elements and modules that might be involved in the regulation of HSR. In order to achieve ...
Development and characterization of pro-apoptotic drug candidates for anticancer drug discovery
(2013)
Cancer is one of the leading causes of death worldwide. According to the WHO, cancer accounted for 7.4 million deaths world wide in 2004. The metallo-compound cisplatin has been used for years as an effective antitumor ...
Investigation of anti-cancer potential of Pleiocarpa pycnantha leaves
(University of the Western Cape, 2013)
The Apocynaceae family is well known for its potential anticancer activity. Pleiocarpamine isolated from the Apocynaceae family and a constituent of Pleiocarpa pycnantha has been reported for anti-cancer activity. Prompted ...
Deciphering a potential cytoprotective role of novel heat shock responsive proteins using a proteomic approach
(University of the Western Cape, 2011)
Myocardial infarction, commonly known as a heart attack, is a condition where the blood supply to the heart tissue is cut off, starving the tissue from oxygen and nutrient supply, with consequent lethal damage to the heart ...