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Computational strategies to identify, prioritize and design potential antimalarial agents from natural products
(University of the Western Cape, 2015)
Introduction: There is an exigent need to develop novel antimalarial drugs in view of the mounting disease burden and emergent resistance to the presently used drugs against the malarial parasites. A large amount of natural ...
Ursolic acid and oleanolic acid as novel therapeutic agents in breast cancer
(University of the Western Cape, 2015)
Breast cancer is one of the most common cancers among women in South Africa and the second leading cause of cancer death after lung cancer. According to the American Cancer Society 2015, women have a 12% chance of developing ...
The phylogeography, epidemiology and determinants of Maize streak virus dispersal across Africa and the adjacent Indian Ocean Islands
(University of the Western Cape, 2015)
Maize streak disease (MSD), caused by variants of the Maize streak virus (MSV) A strain, is the world's third and Africa’s most important maize foliar disease. Outbreaks of the disease occur frequently and in an erratic ...
The effects of Ethanol and Aspalathus linearis on immortalized mouse brain endothelial cells (bEnd5)
(University of the Western Cape, 2015)
The blood brain barrier (BBB) is a signaling interface between the blood and the central nervous system (CNS), which prohibits the entry of harmful blood-borne substances into the brain micro-environment, thus maintaining ...
Factors affecting the enrolment rate of students in higher education institutions in the Gauteng province, South Africa : based on General Household Survey 2012
(University of the Western Cape, 2015)
Background: In South Africa, many students are not able to register at higher education institutions after receiving their high school diploma. The majority of those who do register do not even complete their tertiary ...
Diversity of Frankia associated with Morella species of the Cape floristic region of Southern Africa
(University of the Western Cape, 2016)
Frankia is one of two partners in the globally distributed N2-fixing actinorhizal symbiosis between this filamentous soil-dwelling actinomycete and almost 300 species of host plants from eight diverse angiosperm families. ...
Screening bacterial symbionts of marine invertebrates for ribosomally synthesized natural products
(University of the Western Cape, 2016)
Pharmaceutical research and development strategies rely on the constant discovery of novel natural products as potential drugs. Recent studies have shown that the
microorganisms associated with sponges are the true producers ...
Efavirenz pre-formulation study : selection of a cyclodextrin inclusion complex or co-crystal complex for tabletting
(University of the Western Cape, 2015)
Efavirenz is a non-nucleoside reverse transcriptase inhibitor used as an anti-retroviral for the treatment of human immunodeficiency virus (HIV) type I. It is classified as a class IΙ drug under the Biopharmaceutical ...
The effect of co-crystallization and polymorphism on the physicochemical properties of amoxicillin tri-hydrate
(University of the Western Cape, 2013)
Many active pharmaceutical ingredients (APIs) have poor physicochemical properties such as solubility, dissolution and chemical stability. Several strategies are used to enhance and improve these properties of the API. ...
Polyamic acid-graphene oxide nanocomposite for electrochemical screening of antibiotic residues in water
(University of the Western Cape, 2015)
Pollution of water sources, aquifers and wetland systems caused by industry, agriculture, and municipally treated wastewater is a worldwide problem that contributes to the scarcity of clean and potable water. Rivers, ...