Browsing Department of Medical BioSciences by Title
Now showing items 37-56 of 230
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The development and implementation of biomarker assays for estrogenic endocrine disruptors
(University of the Western Cape, 2008)Endocrine disrupting chemicals (EDCs) are compounds found in the environment that have the potential to disrupt normal endocrine function. Estrogenic EDCs (e-EDCs) is a subclass of EDCs and is defined as substances ... -
The development of targeting nanosystems for the treatment of glioblastoma and neuroblastoma tumours
(University of the Western Cape, 2022)Chlorotoxin (CTX) peptide selectively targets glioblastoma multiforme (GB) and neuroblastoma (NB) and has excellent blood-brain barrier permeability. Therefore, CTX is a promising targeting molecule for nanoparticle (NP) ... -
Dexamethasone's impact on LPS-induced inflammation of blood-brain barrier endothelial cells
(University of the Western Cape, 2023)The blood-brain barrier (BBB) serves as a protective and regulatory barrier between the blood and the brain. Microvascular endothelial cells provide homeostatic regulation of the central nervous system (CNS). BBB integrity ... -
Differential toxicity of two murine endothelial cells to ROS duress: Understanding oxidative stress-induced blood-brain barrier dysfunction
(University of the Western Cape, 2020)The blood-brain barrier (BBB) is a critical interface between the blood circulation and brain tissue which performs critical selection of circulating molecules that gain access to the brain tissue. Its unique ability to ... -
The distribution of the desert rain frog (breviceps macrops) in South Africa
(2009)The Distribution of the Desert Rain Frog (Breviceps macrops) in South Africa Kirsty Jane Bell M.Sc. Thesis, Department of Biodiversity and Conservation Biology, University of the Western Cape. The desert rain frog (Breviceps ... -
Do physiotherapy students employ evidence-based practice in the management of musculoskeletal disorders and sports injuries
(2013)Background: Musculoskeletal disorders (MSD’s) and sports injuries are commonly sustained throughout the world daily. They are dominant in many countries, with considerable cost involvement and impact on quality of life. ... -
Does maternal nicotine exposure during gestation and lactation change the oxidant-antioxidant status of the lungs of the offsprings and is tomato juice protecting the lungs of the offsprings?
(University of the Western Cape, 2009)Nicotine exposure to the fetus through tobacco smoking or nicotine replacement therapy during the whole period of gestation and lactation causes diverse effects on fetal and neonatal lung development, integrity and maturation ... -
Does Olea africana protect the heart against ischemiareperfusion injury?
(2009)Cardiovascular disease is a major health problem and remains the number one cause of death worldwide. For centuries, medicinal plants have been used in different cultures as medicines for the treatment and control of various ... -
Ecology and conservation of high altitude amphibians
(UWC, 2002)This study looked at the breeding ecology of the anurans, found in the Landdroskop mountain range in Grabouw, and some recommendations as to their conservation are made. There is very little known about the frogs in South ... -
Effect of basella alba and hibiscus macranthus on tm4 sertoli cell functions
(University of the Western Cape, 2009)Basella alba (BA) and Hibiscus macranthus (HM) are used by traditional healers in Cameroon to treat male sexual fertility problems. Previous studies showed that in vivo administration of the leaf extracts of both plants ... -
The effect of cissampelos capensis extract on prostate cancer, sertoli and leydig cell function
(University of the Western Cape, 2014)This study investigated the effect of the C. capensis extract (0.001, 0.01, 0.1, 1, 10, 100 1000 μg/ml) on LNCaP prostate cancer, TM3 Leydig and TM4 Sertoli cells for 24 and 96 hours. The following parameters were investigated: ... -
Effect of cissampelos capensis rhizome extract on human sperm capacitation and acrosome reaction
(2013)Cissampelos capensis, is commonly known by the Afrikaans name ‟dawidjies” or ‟dawidjieswortel”. C. capensis is the most important and best known medicinal plant of the family Menispermaceae used by the Khoisan and other ... -
The effect of doxorubicin encapsulated chitosan alginate nanoparticles and curcumin on multidrug resistant colon cancer cell lines
(University of the Western Cape, 2024)Purpose: Although chemotherapeutic drugs have improved the survival rate of patients diagnosed with colorectal cancer, resistance to chemotherapy frequently leads to therapeutic failure and poor patient outcomes. Multidrug ... -
Effect of Eurycoma longifolia (Tongkat Ali) on the prostate cancer cell line LNCaP
(2013)Eurycoma Longfolia Jack, also known as Tongkat Ali (TA) is a tropical plant belonging to the family of Simaroubaceae is widely distributed in South East Asian countries. The extracts of TA have been proven to have ... -
The effect of flavonoids on the in vitro activity of antibiotics against Staphylococcus aureus
(University of the Western Cape, 2012)Staphylococcus aureus is a Gram-positive coccus belonging to the Stapylococcaeae family. S. aureus causes a wide range of infections that range from skin infections to lifethreatening infections such as pneumonia and ... -
The effect of glycine supplementation on the skeletal muscle properties of captive cheetahs (Acinonyx jubatus)
(University of the Western Cape, 2022)The fastest known land mammal – the cheetah, possesses many anatomical adaptations that enables high-speed running. Current literature regarding the physiological aspects that facilitate their incredible sprinting ability, ... -
The effect of gonadotropin-releasing hormones (GnRH) I & II on sperm motility and acrosome status of the Vervet monkey (Chlorocebus aethiops) in vitro
(University of the Western Cape, 2006)Gonadotropin Releasing Hormone (GnRH) is a hypothalmic decapeptide, which regulates mammalian gonadotropin secretions by binding to specific, high affinity receptors in the pituitary. Two forms of GnRH (GnRH I and GnRH II) ... -
The effect of Libyan date palm pollen and flax seed on general and specific properties of testicular and breast cancer cells
(University of the Western cape, 2016)There is increasing concern worldwide by researchers with regards to the assessing of safety and therapeutic consumption of the plants used in traditional medicine. Date palm pollen (DPP) and flax seed have been used ... -
The effect of maternal exposure to alcohol and nicotine on pancreas and kidney size, aorta and carotid intima thickness and visceral fat in their children.
(University of Western Cape, 2019)In utero exposure to teratogens, increasing urbanization, rapid nutritional transition from poverty to affluence, adoption of a Western-style diet and physical inactivity have contributed to the growing obesity epidemic ... -
The effect of maternal nicotine exposure on cell proliferation on the lungs of the offspring
(2013)Tobacco consumption and exposure to tobacco smoke is one of the biggest contributing factors to a growing epidemic of non-communicable diseases (NCDs), primarily cancers, diabetes, cardiovascular and chronic lung diseases ...