Browsing Department of Medical BioSciences by Title
Now showing items 212-231 of 232
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The antifungal effect of Salvadora persica and Euclea natalensis on Candida isolates from Libyan patients with type 2 Diabetes mellitus.
(University of the Western Cape, 2018)Improved oral hygiene plays a vital role on quality of health and well-being of diabetic patients. Poor oral health leads to an increased incidence of oral diseases, particularly oral candidiasis. The emergence and global ... -
The assessment of Namibian water resources for endocrine disruptors
(University of the Western Cape, 2018)Namibia is the driest sub-Saharan country in Africa and it is characterised by low and variable rainfall. As a result, potable water in this mostly semi-arid country is considered an extremely valuable resource. Given ... -
The effects of selective inhibitors of N-Glycosylation and Endoplasmic Reticulum stress inducers on Neuroblastoma cell proliferation and Apoptosis
(University of the Western Cape, 2017)Among all childhood cancers diagnosed, neuroblastoma (NB) is the most prevalent during infancy. In patients younger than 15 years, it accounts for more than 7% of malignancies and about 15% of all paediatric mortalities. ... -
The effects of selective inhibitors of n-glycosylation and endoplasmic reticulum stress inducers on the expression of neuroblastoma drug resistance
(University of the Western Cape, 2017)Neuroblastoma (NB) represents 8-10% of all childhood tumours and accounts for approximately 15% of all cancer-related deaths in the paediatric population. Approximately half of newly diagnosed children with this tumour ... -
The evaluation of the cardioprotective effects of Olea containing liposomes
(University of the Western Cape, 2017)High levels of free oxygen radicals, induced by many biological or environmental factors, result in damage and dysfunction of the mitochondria which causes cardiovascular and other diseases. Cardiotherapies employing antioxidants ... -
The Generation of Antibodies against Human Coronavirus NL63 (HCoV-NL63) Nucleocapsid Protein
(University of the Western Cape, 2017)Coronaviruses (CoVs) are enveloped viruses composed of single-stranded, positive sense RNA viruses with the largest viral genomes among RNA viruses (27-33 kb). In 2004, human coronavirus NL63 (HCoV-NL63) was discovered by ... -
The in vitro effects of heavy metals and nanoparticles on the immune system
(University of the Western Cape, 2017)Heavy metals and nanoparticles may be released into the environment due to their use and applications. Sources of high, toxic metal concentrations may result from leachates from hazardous waste sites, discharge from ... -
The role of arylamine N-acetyltransferase 1 (NAT1) in the clinical therapy of tuberculosis
(University of the Western Cape, 2017)Despite attempts to develop new drugs to reduce the worldwide mortality rate attributable to tuberculosis (TB), the illness remains a threat. Isoniazid (INH) has been used as a frontline drug for decades. However, several ... -
The role of the glutathione system in regulating the levels of ROS neutralisation in the endothelial cells of the blood-brain barrier
(University of the Western Cape, 2017)Brain endothelial cell types are frequently used as in vitro models to study the blood-brain barrier (BBB). Oxidative stress (OS) has been reported numerous times to cause BBB dysfunction which is crucial to the initiation ... -
The use of in vitro assays to screen for endocrine modulation
(University of the Western Cape, 2008)Aspalathus linearis (A. linearis), commonly known as Rooibos tea or Red bush tea and Camellia sinensis (C. sinensis) or Black tea are beverages that are consumed throughout the world. These teas possess antioxidant, ... -
The use of whole blood cell cultures as a model for assessing the effects of Septilin on the immune system
(University of the Western Cape, 2017)In the past three decades there has been a huge increase in the use of herbal medicine globally. The active principles of these herbal medicines are mostly unknown with supportive evidence for safety and efficacy very ... -
Toxicology and molecular epidemiology of microbes detected in surface water in the Western Cape: The Impact of Informal Settlement
(University of the Western Cape, 2013)Informal settlements are often implicated in surface water pollution with faecal matter. In most instances faecal pollution in the associated surface waters persists despite improvements in sewage removal infrastructure. ... -
Transient transgene expression of human coronavirus nl63 orf3 protein
(University of the Western Cape, 2020)Insect-derived baculoviruses have been used extensively as a safe and versatile research model for transgenic protein expression. Preclinical studies have revealed the promising potential of Baculoviruses as a delivery ... -
Transient transgene expression of human Coronavirus nl63 orf3 protein in a baculovirus system
(University of Western Cape, 2020)Insect-derived baculoviruses have been used extensively as a safe and versatile research model for transgenic protein expression. Preclinical studies have revealed the promising potential of Baculoviruses as a delivery ... -
Tumour suppression and subdual of cancer (tussc) in elephants: An in vitro study to shed light on Peto’s paradox
(University of the Western Cape, 2022)Logic would suggest that cancer incidence is related to body mass and longevity. Gigantic animals such as elephants with a longer lifespan (more lifetime of cell divisions) and a larger body size (more cells) will have ... -
Typha capensis—An electron rich resource for the synthesis of phytochemical-encapsulated gold nanoparticles through green nanotechnology
(University of the Western Cape, 2020)Typha capensis (T. capensis), commonly known as bulrush, is a medicinal plant found growing in the wetland areas of South Africa. In traditional medicine, rhizome decoctions of T. capensis are used to treat a wide variety ... -
Tyrosol production of Candida species by plant extracts used for skin treatment remedies
(University of the Western Cape, 2022)The fungal genus Candida is a collection of approximately 150 asporogenous yeast species which are able to cause life-threatening diseases when the normal host defences have been compromised. The most commonly isolated ... -
Ursolic acid and oleanolic acid as novel therapeutic agents in breast cancer
(University of the Western Cape, 2015)Breast cancer is one of the most common cancers among women in South Africa and the second leading cause of cancer death after lung cancer. According to the American Cancer Society 2015, women have a 12% chance of developing ... -
The use of ultrasonography for the early detection of cardiovascular risk in adolescents
(University of the Western Cape, 2022)Cardiovascular disease (CVD) is the major cause of mortality and morbidity globally and is the leading cause of death in South Africa second to HIV/AIDS. CVD is on the rise not only in adults but also in children. The ... -
The use of whole blood cell cultures as a model for assessing the effects of SeptilinTM on the immune system.
(University of the Western Cape, 2017)In the past three decades there has been a huge increase in the use of herbal medicine globally. The active principles of these herbal medicines are mostly unknown with supportive evidence for safety and efficacy very ...