Proteome profiling as tool to determine the effectiveness of traditional Africa therapies for Type 2 diabetes mellitus

Abstract

Type 2 diabetes mellitus (T2DM) involves multiple organ dysfunction accompanied by a chronic inflammatory state and oxidative stress resulting from a combination of factors such as hyperglycaemia and dyslipidaemia. Although medication to treat T2DM is currently available, several limitations and harmful effects of anti-hyperglycaemic diabetes synthetic drugs make it necessary to investigate novel drug therapies that are safer and more efficient. The biggest challenges remain in the management of T2DM and its complications. Therefore, it is necessary to prevent the early onset of diabetes and the progression of the disease individually by using pharmacological and traditional therapies.