Browsing Department of Medical BioSciences by Title
Now showing items 21-40 of 230
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Bionomics of vector-borne diseases in sites adjacent to lakes Victoria and Baringo in Kenya
(University of the Western Cape, 2016)Bionomics of vector-borne pathogens (VBPs) is a complex phenomenon that involves understanding the ecology of arthropod borne pathogens and vertebrate hosts potentially involved in their transmission cycles. Investigations ... -
Brine shrimp lethality test and acetylcholine esterase inhibition studies on selected South African medicinal plants
(University of the Western Cape, 2012)Research into traditional medicines is often conducted in a multidisciplinary approach as motivated by a desire to understand them in as complete a manner as possible,realizing their chemistry, biology and pharmacology. ... -
Cell culture biomarkers for monitoring of wastewater pollutants
(University of the Western Cape, 2021)Wastewater is normally composed of a mixture of pollutants. The type and composition of pollutants in a particular wastewater depend on the source of origin. The source and characteristics of a particular wastewater determine ... -
The characterisation of human coronavirus nl63 proteins
(University of Western Cape, 2021)Human Coronavirus NL63 (HCoV-NL63) is one of seven coronaviruses (CoVs) that cause respiratory disease in the global population. The Membrane (M) and Nucleocapsid (N) proteins are part of the core CoV-structural proteins, ... -
Characterization of Candida species isolated from the oral mucosa of HIV-positive African patients
(UWC, 2013)One of the most common HIV-associated opportunistic infections is candidiasis, caused by Candida albicans or other Candida species. In immune suppressed subjects, this commensal organism can cause an increase in patient ... -
Characterization of candida species isolated from the oral mucosa of HIV-positive African patients
(2013)One of the most common HIV-associated opportunistic infections is candidiasis, caused by Candida albicans or other Candida species. In immune suppressed subjects, this commensal organism can cause an increase in patient ... -
CIMT and cardiovascular risk in five-year-old children in a low socioeconomic population exposed to alcohol and nicotine during pregnancy: a case-control study
(University of the Western Cape, 2020)Cardiovascular diseases (CVD) are among the top 10 causes of death in all ages in South Africa. The prevalence of maternal smoking and alcohol consumption during pregnancy is alarmingly high in South Africa. In utero ... -
Circadian activity rhythms and early gene expression in the suprachiasmatic nucleus of a diurnal rodent, Rhabdomys pumilio
(UWC, 2001)Although humans are diurnal in behavior, animal models used for the study of circadian rhythms are mainly restricted to nocturnal rodents. This study focused on circadian behavior and gene expression in a diurnal rodent ... -
Cloning and characterization of the human coronavirus NL63 nucleocapsid protein
(University of the Western Cape, 2011)The human coronavirus NL63 was discovered in 2004 by a team of researchers in Amsterdam. Since its discovery it has been shown to have worldwide spread and affects mainly children, aged 0-5 years old, the immunocompromised ... -
Cloning and expression of human cyclophilin A and its interaction with human coronavirus NL63 nucleocapsid protein
(University of the Western Cape, 2011)Coronaviridae family is composed of a number of ribonucleic acid (RNA)-containing viruses currently classified into two genera, the coronavirus and torovirus. The family is classified together with the Arteviridae in the ... -
Cloning and expression of the M-gene from the human coronavirus NL-63 in different expression systems
(University of the Western Cape, 2008)Respiratory tract infections are one of the leading causes of morbidity and mortality across the world. This is especially true for infants, young children, the elderly and the immunocompromised. The strain placed on ... -
Cloning of Human Coronavirus NL-63 ORF3, M and E genes for antibody production
(University of the Western Cape, 2010)Human Coronavirus NL-63 is a respiratory virus with a high incidence rate, causing mild respiratory infections in children under the age of 18. The outbreak of Sever Acute Respiratory Syndrome (SARS) in 2003 sparked increased ... -
Comparative in vitro study of the anti-cancer effect of apricot and peach kernel extracts on human colon cancer cells
(University of the Western Cape, 2015)Amygdalin, a controversial anti-cancer agent, is a cyanogenic glycoside plant compound found in apricot and peach kernels. Both amygdalin and its patented form, Laetrile®, have been promoted and sold as "vitamin B-17", ... -
Comparison between chemical and tissue culture methods to monitor environmental estrogens
(University of the Western Cape, 2012)Endocrine disrupting compounds (EDCs) are exogenous compounds/chemicals in the environment that interfere with the synthesis, secretion, distribution and function or elimination of natural hormones in the body. Environmental ... -
Comparison between chemical and tissue culture methods to monitor environmental Estrogens
(University of the Western Cape, 2012)Endocrine disrupting compounds (EDCs) are exogenous compounds/chemicals in the environment that interfere with the synthesis, secretion, distribution and function or elimination of natural hormones in the body. Environmental ... -
A comparison of some aspects of the masticatory apparatus of the cape mole-rat, Georychus capensis with that of the cape dune molerat, Bathyergus suillus
(2009)Some African mole-rats of the family Bathyergidea have dramatically different ecological niches which may cause selective anatomical adaptations. Bathyergus suillus lives in sandy soil and eats a wide range of food whereas ... -
The development and implementation of biomarker assays for estrogenic endocrine disruptors
(University of the Western Cape, 2008)Endocrine disrupting chemicals (EDCs) are compounds found in the environment that have the potential to disrupt normal endocrine function. Estrogenic EDCs (e-EDCs) is a subclass of EDCs and is defined as substances ... -
The development of targeting nanosystems for the treatment of glioblastoma and neuroblastoma tumours
(University of the Western Cape, 2022)Chlorotoxin (CTX) peptide selectively targets glioblastoma multiforme (GB) and neuroblastoma (NB) and has excellent blood-brain barrier permeability. Therefore, CTX is a promising targeting molecule for nanoparticle (NP) ... -
Dexamethasone's impact on LPS-induced inflammation of blood-brain barrier endothelial cells
(University of the Western Cape, 2023)The blood-brain barrier (BBB) serves as a protective and regulatory barrier between the blood and the brain. Microvascular endothelial cells provide homeostatic regulation of the central nervous system (CNS). BBB integrity ... -
Differential toxicity of two murine endothelial cells to ROS duress: Understanding oxidative stress-induced blood-brain barrier dysfunction
(University of the Western Cape, 2020)The blood-brain barrier (BBB) is a critical interface between the blood circulation and brain tissue which performs critical selection of circulating molecules that gain access to the brain tissue. Its unique ability to ...