Microscopic analysis of In vitro and In vivo effects of functionalized gold nanoparticles on the liver, kidney, spleen, heart and pancreas of male wistar rats

Abstract

Nanotechnology represents a promising knowledge based platform that can solve human needs and ailments, especially in cases like cancers, diabetes, antibiotic drug resistances etc. Many metallic nanoparticles are being employed today to deliver drugs and other moieties to biological systems, however gold nanoparticles (AuNPs) is preferred because they are optically stable and easily manipulated to produce nanomaterials. However, AuNPs cytotoxicity have been reported in living systems, hence scientists are pushing boundaries to design more effective and biocompatible AuNPs. In this study, in vitro effects of 14 nm, citrate capped, chemically synthesized AuNPs (cAuNPs) on Caco-2 cells.