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Now showing items 1-10 of 14
Knowledge, perceptions and practices of risk-based monitoring among clinical practitioners in the United States
(University of the Western Cape, 2018)
This study investigated the current knowledge, perceptions, and practices of Risk-Based Monitoring (RBM) using written and verbal responses to an ethics review board approved questionnaire. Responses were collected from ...
The development and preparation of a quality control dossier for registration of Artemisia Afra capsules for the treatment of chronic Asthma by the South African health products regulatory authority
(University of the Western Cape, 2018)
The aim of this study was to determine quality control specifications needed for a dossier and an investigator's brochure of A. afra capsules, which can be used to motivate the registration and clinical testing of A. afra ...
Discovery of cytotoxic natural products from South African marine sponges
(University of the Western Cape, 2018)
Cancer is a major health problem worldwide and killing millions of people each year. The use
of natural products as chemotherapeutic agents is well established, however, many of the
currently available drugs are associated ...
Review of the effectiveness of the medicines regulatory systems in Zambia over the period 1995 to 2015
(University of the Western Cape, 2018)
Due to inadequacy of data on the effectiveness of medicines regulatory systems in Zambia, this study
was framed. The aim was to evaluate legislative provisions for medicines regulation under three legalregulatory-
frameworks ...
Polycyclic propargylamine derivatives as multifunctional neuroprotective agents
(University of the Western Cape, 2018)
The abnormal death of neurons in the central nervous system of individuals suffering from neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis, ...
Formulation and evaluation of polymeric micelles for improved oral delivery of tenofovir disoproxil fumarate and zidovudine using poly-lactic-co-glycolic acid nanoparticles
(University of the Western Cape, 2018)
Background: Tenofovir disoproxil fumarate (TDF) and Zidovudine (AZT) are both nucleotide and nucleoside analogue reverse transcriptase inhibitors (NtRTIs and NRTIs), respectively. They are used for the management and ...
Design and evaluation of fast dispersible tablets of lamivudine using selected natural superdisintegrants
(University of the Western Cape, 2018)
Fast dispersible tablets (FDTs) are solid single-unit dosage forms that are placed in the mouth and allowed to disperse or dissolve in the saliva without the need of water. The basic approach to formulating FDTs consists ...
The development of a study protocol, and ethics and regulatory approval documentation, for evaluation of clinical efficacy of Sutherlandia frutescens in adult type-2 diabetics
(University of the Western Cape, 2018)
The prevalence of diabetes mellitus is increasing worldwide and it is becoming a significant
medical problem in low- and middle-income countries. The condition can be controlled
with a lifelong commitment to blood sugar ...
Review of the effectiveness of the medicines regulatory systems in Zambia over the period 1995 to 2015
(University of the Western Cape, 2018)
Due to inadequacy of data on the effectiveness of medicines regulatory systems in Zambia, this study
was framed. The aim was to evaluate legislative provisions for medicines regulation under three legalregulatory-
frameworks ...
Community pharmacists’ knowledge, attitude and practices on adverse drug reaction reporting in South Africa
(University of the Western Cape, 2018)
Pharmacovigilance involves the management of sub-standard drugs, medication
errors, ―off-licence‖ drugs, abuse and misuse, lack of efficacy, poisoning, adverse
drug reactions (ADRs), drug interactions, expired stock ...