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Formulation and evaluation of zidovudine cyclodextrin inclusion complex to enhance acid lability and palatability
(University of the Western Cape, 2016)
Background: Zidovudine (AZT) is a very useful drug for the management of Human
Immunodeficiency Virus (HIV) infection. Its optimal use is limited by its bitter taste, sparing solubility (20.1 mg/ml) and acid lability. ...
In-silico optimization and molecular validation of putative anti-HIV antimicrobial peptides for therapeutic purpose
(University of the Western cape, 2016)
AIDS is considered a pandemic causing millions of deaths worldwide and a cure for this disease is still not available. Failure to implement early treatments due to the poor diagnostic
methods and ineffective therapeutic ...
Mathematical modeling and analysis of HIV/AIDS control measures
(University of the Western Cape, 2012)
In this thesis, we investigate the HIV/AIDS epidemic in a population which experiences a significant flow of immigrants. We derive and analyse a math-
ematical model that describes the dynamics of HIV infection among the ...
Determination of kanamycin plasma concentrations using LC/MS and pharmacokinetics of kanamycin in patients with multidrug-resistant tuberculosis and in patients with multidrug-resistant tuberculosis co-infected with HIV
(University of the Western Cape, 2012)
The aim of the study was to determine firstly, kanamycin plasma concentrations using liquid chromatography coupled with mass spectrometry (LC/MS); secondly, to investigate the PK parameters of kanamycin in patients infected ...
Determination of plasma concentrations using LC/MS and pharmacokinetics of ofloxacin in patients with multi-drug resistant tuberculosis and in patients with multi-drug resistant tuberculosis coinfected with hiv
(2009)
Many studies have investigated the pharmacokinetics of anti-tuberculosis drugs in
patients infected with tuberculosis. However, little is known about the pharmacokinetics of the drugs that are used in the treatment of ...
Socio-demographic characteristics and HIV testing in Omdurman National Voluntary Counseling and Testing (VCT) in Sudan by Reem Mutwali
(UWC, 2008)
The identification of the association between socio-demographic characteristics and HIV was found to be a useful tool in determining the important risk factors in Sudan. In this study, the relationship(s) between HIV test ...
The utilisation of HIV services on campus by the students of the University of the Western Cape
(University of the Western Cape, 2009)
This qualitative study was conducted from June to November 2009, using designed questionnaires for sixty three (63) registered students and five (5) HIV program staff .The main reason for this study was to understand the ...
An investigation into the medicinal properties of Tulbaghia alliacea phytotherapy
(University of the Western Cape, 2009)
The reproductive health of individuals is severely compromised by HIV infection, with candidiasis being the most prevalent oral complication in patients. Although not usually associated with severe morbidity, oropharyngeal ...
Molecular dynamic simulation studies of the South African HIV-1 Integrase subtype C protein to understand the structural impact of naturally occurring polymorphisms
(University of the Western Cape, 2021)
The viral Integrase (IN) protein is an essential enzyme of all known retroviruses, including HIV-1. It is responsible for the insertion of viral DNA into the human genome. It is known that HIV-1 is highly diverse with a ...
An assessment of current practice patterns of TB/HIV at primary health care clinics in the Western Cape and a needs assessment for clinic-based training among final year pharmacy students
(University of the Western Cape, 2010)
Tuberculosis and mv
Tuberculosis (TB) is a major contributor to the disease burden in developing countries
resulting in the deaths of approximately 2 million people a year. South Africa (SA) has one (
of the highest ...