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Genome assembly of next-generation sequencing data for the Oryx bacillus : species of the Mycobacterium tuberculosis complex
(University of the Western Cape, 2011)
Next generation sequencing (NGS) technology platforms have accelerated ability to
produce completed genome assemblies. Recently, collaborators at Tygerberg Medical
School outsourced the sequencing of Oryx bacillus, a ...
Computational characterisation of DNA methylomes in mycobacterium tuberculosis Beijing hyper- and hypo-virulent strains
(University of the Western Cape, 2014)
Mycobacterium tuberculosis, the causative agent of tuberculosis, is estimated to infect approximately one-third of the world’s population and is responsible for around 2 million deaths per year. The disease is endemic in ...
Investigating the functional interaction of transcription regulator CarD of Mycobacterium tuberculosis with Ribonucleic Acid Polymerase
(University of the Western Cape, 2014)
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb). TB mainly affects lungs of patients but other parts of the body can also be affected. It kills approximately 2 million people annually. ...
Structural analysis of induced mutagenesis A’ protein from mycobacterium tuberculosis and of a thermophillic GH9 cellulase
(University of the Western Cape, 2014)
The three-dimensional structures of proteins are important in understanding their function and interaction with ligands and other proteins. In this work, the structures of two proteins, ImuA’ from mycobacterium tuberculosis ...
Development of nanobiosensors for phenolic endocrine disrupting compounds and anti- tuberculosis drugs
(2013)
Tuberculosis still remains one of the world’s killer diseases. Pyrazinamide (PZA) is one of
the most commonly prescribed anti-tuberculosis (anti-TB) drugs due to its ability to
significantly shorten the TB treatment ...
Investigating the functional interaction of transcription regulator card of mycobacterium tuberculosis with ribonucleic acid polymerase
(2013)
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb). TB mainly affects lungs of patients but other parts of the body can also be affected. It kills approximately 2 million people annually. ...
Treatment outcomes in patients infected with multidrug resistant tuberculosis and in patients with multidrug resistant tuberculosis coinfected with human immunodeficiency virus at Brewelskloof Hospital
(University of the Western Cape, 2012)
Many studies have reported low cure rates for multidrug-resistant tuberculosis (MDRTB) patients and MDR-TB patients co-infected with human immunodeficiency virus (HIV). However, little is known about the effect of HIV ...
Nanoparticulate of silver-modified poly (8-anilino-1-naphthalene sulphonic acid) nanobiosensor systems for the determination of Tuberculosis treatment drugs
(University of the Western Cape, 2011)
This study firstly reports the development and characterization of PVP-AgNPs, PANSA and PVPAgNPs/ PANSA nanocomposite on gold. AFM and TEM analyses revealed highly electroactive nanocomposites whose morphogy and properties ...
Ethionamide pharmacokinetics in multidrugresistant tuberculosis patients with and without HIVinfection
(University of the Western Cape, 2017)
Many studies have investigated the pharmacokinetics (PK) of anti-tuberculosis drugs
in tuberculosis patients. However, currently in South Africa, no studies have been
done on ethionamide (ETH) PK in adult MDR-TB patients ...
Computational prediction of host-pathogen protein-protein interactions
(University of the Western Cape, 2017)
Supervised machine learning approaches have been applied successfully to the prediction of protein-protein interactions (PPIs) within a single organism, i.e., intra-species predictions. However, because of the absence of ...