Browsing Department of Medical BioSciences by Title
Now showing items 103-122 of 230
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Fatty acids as cancer preventive tools in the dietary modulation of altered lipid profiles associated with hepatocarcinogenesis
(University of the Western Cape, 2005)This thesis consists of a brief description on cancer, carcinogenesis, the changes in the type and level of dietary fat available in our diets over time and association with the development of certain diseases. The main ... -
Formulation and evaluation of the biocompatibility of chitosan-dextran nanoparticles using a blood-brain barrier model
(University of the Western Cape, 2018)Central nervous system (CNS) infections are a therapeutic challenge. This is partly due to insufficient drug penetration across the blood-brain barrier (BBB). The BBB is a specialized, highly selective, metabolically active ... -
The frequency and characterization of streptococci in aerobic vaginitis (AV) and its association with pregnancy outcomes
(University of the Western Cape, 2014)The aim of the study was to detect the prevalence of AV and its associated bacteria with preterm delivery in the Western Cape, South Africa. Furthermore, it sought particularly to examine and investigate the predictive ... -
Gene expression of xenobiotic metabolising enzymes in rat liver and kidney: differential effects of rooibos and honeybush herbal teas
(2011)Laboratory studies, epidemiological investigations and human clinical trials indicate that flavonoids have important effects on cancer chemoprevention and therapy. Flavonoids may interfere in several steps that lead to ... -
Holarrhena floribunda leaves as a potential source of bioactive anticancer compounds
(University of the Western Cape, 2014)Cancer is one of the leading causes of morbidity and mortality in developed and developing nations. It is estimated that 86% of new cases and 64% of death due to cancer are from Africa and 13.1 million deaths are estimated ... -
Hyperactivation in human semen and sperm subpopulations by selected calcium modulators
(University of the Western Cape, 2014)A functional sperm is critical for successful fertilization in order to deliver an intact genome to the site of fertilization. It is often characterized by high motility and normal morphology. Moreover, sperm hyperactivated ... -
Hyperglycinemia in captive-bred vervet monkeys with cataracts: genetic dynamics and associations
(University of the Western Cape, 2017)A small percentage (8%) of the captive-bred vervet monkeys (Chlorocebus aethiops) maintained at Primate Unit and Delft Animal Centre (PUDAC) of the South African Medical Research Council (SAMRC) were found to have high ... -
Identification and characterisation of cephalosporins and carbapenem-resistant Klebsiella pneumoniae isolates from Misrata, Libya
(University of the Western Cape, 2018)Background: Extended-spectrum beta-lactamase-producing (ESBL) and carbapenemaseproducing Gram-negative bacilli showing resistance to cephalosporins and carbapenems respectively, have been reported from several countries ... -
Identification and validation of putative therapeutic and diagnostic antimicrobial peptides against HIV: An in silico approach
(University of the Western Cape, 2013)Background: Despite the effort of scientific research on HIV therapies and to reduce the rate of HIV infection, AIDS remains one of the major causes of death in the world and mostly in sub-Saharan Africa. To date, neither ... -
The identification of novel biomarkers in response to pollutant exposure using proteome profiler arrays
(University of Western Cape, 2020)Nanotechnology is a rapidly expanding field with a multitude of practical uses namely textiles, cosmetics, agriculture, and health sciences. The focus, for the purposes of this thesis, will be on carbon dots. The small ... -
Immunohistochemical analysis of a panel of human and murine markers on xenografted human vaginal mucosa: a comparative study
(University of the Western Cape, 2012)Athymic nude mouse models have been extensively used to study biological behaviour of normal and diseased human tissues. In such models, immune-deficient mice act as hosts for cysts constructed from human material. A unique ... -
The impact of nanoparticles on the proteome of cultured human cells
(2021)Living organisms are constantly being exposed to nanoparticles (NPs) in the environment via air, water, soil. Routes of exposure are usually in the form of industrial, occupational exposure, as well as therapeutic ... -
The implementation of in vitro assays to screen environmental samples for male reproductive toxicity
(University of the Western Cape, 2010)Endocrine disrupting compounds (EDCs) are exogenous compounds/chemicals which interfere with, or have adverse effects on the production, distribution and function of natural hormones, thereby affecting normal endocrine ... -
The in vitro effects of nicotine and selected antibiotics, tunicamycin and thapsigargin on human Breast carcinoma (mcf-7) cells.
(University of the Western Cape, 2012)Cancer is defined as the abnormal growth of genetically mutated or perturbant cells. Nicotine is a known cancer promoter and an apoptotic suppressor. This alkaloid acts on the nicotinic acetylcholine receptors which affects ... -
The in vitro effects of pure and street methamphetamine on the proliferation and cell cycle of mouse brain endothelial (bend5) cells
(2012)The blood-brain barrier (BBB) is an interface between the brain parenchyma and the circulating system. This barrier plays a vital role in protecting the CNS by restricting free paracellular diffusion of molecules from the ... -
In vitro effects of rooibos herbal tea (Aspalathus linearis) against methamphetamine on the mouse blood brain barrier
(University of the Western Cape, 2014)Methamphetamine (MA), also known as ‘Tik’, has detrimental short- and long-term psychological and morphological effects on the central nervous system (CNS). The lipophilic nature of MA allows it to cross the blood-brain ... -
An in vitro investigation of the effects of camellia sinensis and aspalathus linearis on benign (RPWE 1) and malignant (LNCaP) prostate cell lines
(University of the Western Cape, 2015)The prostate is prone to three pathological processes that include inflammation, benign prostate hyperplasia (BPH) and tumors. According to the center for Disease and Control 1999-2012 report, prostate cancer is the second ... -
In vitro modulatory effects of fermented rooibos extract (Aspalathus linearis) against ethanol-induced effects on the mouse blood-brain barrier
(University of the Western Cape, 2014)Alcohol abuse is a growing crisis within South Africa, with severe health and socio-economic implications. Alcohol compromises the function of the blood-brain barrier (BBB), and thus its ability to regulate the homeostatic ... -
In vitro neuroprotective effects of boophone disticha, brunsvigia bosmaniae and strumaria truncata extracts in sh-sy5y cells.
(University of Western Cape, 2021)Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease, is one of the leading disability disorders with about 10 million people affected worldwide. The pathological hallmarks ... -
In vitro neuroprotective potential of phyllanthin in MPP+- induced toxicity in SH-SY5Y neuroblastoma cells
(University of the Western Cape, 2023)Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s disease, with an estimated 9 million people projected to be affected worldwide by the year 2030. PD is associated ...