Department of Medical BioSciences: Recent submissions
Now showing items 21-40 of 230
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Microscopic analysis of In vitro and In vivo effects of functionalized gold nanoparticles on the liver, kidney, spleen, heart and pancreas of male wistar rats
(University of the Western Cape, 2022)Nanotechnology represents a promising knowledge based platform that can solve human needs and ailments, especially in cases like cancers, diabetes, antibiotic drug resistances etc. Many metallic nanoparticles are being ... -
The effect of Nicotine exposure on aspects of liver Carbohydrate metabolism
(University of the Western Cape, 1989)The liver plays an important role in maintaining the blood glucose concentration. In this respect glycogenolysis and gluconeogenesis play an important role. Interference with these pathways may therefore have an effect on ... -
Aspects of the reproductive physiology of male vervet monkeys maintained in a laboratory environment
(University of the Western Cape, 1995)In biomedical research limited use has been made internationally of African non-human primates. As a result, their reproductive physiology has been less well defined, when compared to the more commonly used macaque species. ... -
An evaluation of the biopesticidal characteristics of Hetichrysum marifolium and Helichrysum patulum and their effects on animal metabolism
(University of the Western Cape, 2002)There ate a number of pesticides that are suspected to be endocrine disrupters' Many of these pesticides are man-made. Endocrine disrupters are chemicals that can lead to an increase in birth defects, sexual abnormalities, ... -
An assessment of carpobrotrn actnacifurmis and cissampelos capensis as potential antimicrobial agents and their effects on animal metabolism
(University of the Western Cape, 2002)An assessm entof Carpobrotus acinaciformib and Cissampelos capensis as potential antimicrobialagentsandtheireffectsonanimalmetabolism -
A molecular investigation of the prevalence of suspected periodontopathogens and their association with preterm birth
(University of the Western Cape, 2010)More than 20 million infants in the world (15.5 % of all births) are born with low birth weight. Ninety-five % of them are in developing countries. oral colonization of gram-negative anaerobes has been implicated as a risk ... -
Nanostructured immunosensor for low level detection of waterborne cryptosporidium
(University of the Western Cape, 2022)A major causative agent of gastrointestinal disease is Cryptosporidium, a protozoan waterborne parasite identified in over 70 countries. Cryptosporidium infection is a cause of high disease morbidity in children and the ... -
The effect of glycine supplementation on the skeletal muscle properties of captive cheetahs (Acinonyx jubatus)
(University of the Western Cape, 2022)The fastest known land mammal – the cheetah, possesses many anatomical adaptations that enables high-speed running. Current literature regarding the physiological aspects that facilitate their incredible sprinting ability, ... -
The effects of PGA2 on cell cycle progression in oesophageal carcinoma cells
(University of the Western Cape, 2003)The molecular mechanisms causing anti-mitotic and cytotoxic effects of prostaglandin .A2 [PGA2 (CzoHroOa)] treatment of human oesophageal carcinoma (WHCO3) cells were investigated. WHCO3 cells, incubated with cytotoxic ... -
Synthesis and characterization of magneto-electric nanoparticles for delivery of antituberculosis drugs across the blood-brain barrier
(University of the Western Cape, 2022)The anatomical structure of the brain at the blood–brain barrier (BBB) creates a limitation for the movement of drugs into the central nervous system (CNS). Although anti-infective drugs effective against Mycobacterium ... -
Investigation of the in vitro antidiabetic and neuroprotective effects of selected Helichrysum species against high monosaccharide-induced toxicity
(University of the Western Cape, 2022)Chronic hyperglycaemia (glucotoxicity), a common complication in diabetes mellitus (DM), is known to cause cognitive decline in some of these patients, often affecting their overall quality of life. Some medicinal plants ... -
An evaluation of the biopesticidal characteristics of Helichrysum marifolium and Helichrysum patulum and their effects on animal metabolism
(University of the Western Cape, 2002)There ate a number of pesticides that are suspected to be endocrine disrupters' Many of these pesticides are man-made. Endocrine disrupters are chemicals that can lead to an increase in birth defects, sexual abnormalities, ... -
Proteome profiling as tool to determine the effectiveness of traditional Africa therapies for Type 2 diabetes mellitus
(University of the Western Cape, 2022)Type 2 diabetes mellitus (T2DM) involves multiple organ dysfunction accompanied by a chronic inflammatory state and oxidative stress resulting from a combination of factors such as hyperglycaemia and dyslipidaemia. Although ... -
''A molecular investigation of the prevalence of suspected periodontopathogens and their association with preterm birth.''
(University of the Western Cape, 2010)More than 20 million infants in the world (15.5 % of all births) are born with low birth weight. Ninety-five oZ of them are in developing countries. Oral colonization of Gramnegative anaerobes has been implicated as a risk ... -
lnvestigations into the cancer modulating properties of Aspalathus linearis (Rooibos), Cyclopia intermedia (Honeybush) and Sutherlandia frutescens (Cancer bush) in oesophagea! carci nogenesis
(University of the Western Cape, 2007)This thesis contains scientific evidence on the anticancer properties of two unique South African herbal teas, rooibos and honeybush, and the herbal plant Sutherlandia frutescens (cancer bush) using an in vivo oesophageal ... -
An assessment of Carpobrotus acinaciformis and Cissampelos capensis as potential antimicrobial agents and their effects on animal metabolism
(University of the Western Cape, 2002)The definition of a medicinal plant (as formulated by the WHO) is a plant that consists of either one or more plant parts with therapeutic properties that can be used in the development of drugs (sofowora lg82). Various ... -
An evaluation of the biopesticidal characteristics of Helichrysum marifolium and Hetichrysum patulum and their effects on animal metabolism
(University of the Western Cape, 2002)There ate a number of pesticides that are suspected to be endocrine disrupters' Many of these pesticides are man-made. Endocrine disrupters are chemicals that can lead to an increase in birth defects, sexual abnormalities, ... -
The use of ultrasonography for the early detection of cardiovascular risk in adolescents
(University of the Western Cape, 2022)Cardiovascular disease (CVD) is the major cause of mortality and morbidity globally and is the leading cause of death in South Africa second to HIV/AIDS. CVD is on the rise not only in adults but also in children. The ... -
The development of targeting nanosystems for the treatment of glioblastoma and neuroblastoma tumours
(University of the Western Cape, 2022)Chlorotoxin (CTX) peptide selectively targets glioblastoma multiforme (GB) and neuroblastoma (NB) and has excellent blood-brain barrier permeability. Therefore, CTX is a promising targeting molecule for nanoparticle (NP) ... -
The prevalence, risk factors and serotypes of GBS in Libyan women at labour and the rate of vertical transmission of GBS from mother to infant
(University of the Western Cape, 2022)Group B Streptococcus (GBS) also known as Streptococcus agalactia, is one of the most important causes of serious neonatal infections. Early detection of GBS colonisation in the mother is thus of primary importance to ...