Browsing Magister Scientiae - MSc (Bioinformatics) by Title
Now showing items 32-44 of 44
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A knowledgebase of stress reponsive gene regulatory elements in arabidopsis Thaliana
(University of the Western Cape, 2011)Stress responsive genes play a key role in shaping the manner in which plants process and respond to environmental stress. Their gene products are linked to DNA transcription and its consequent translation into a response ... -
Market segmentation and factors affecting stock returns on the JSE
(2008)This study examines the relationship between stock returns and market segmentation. Monthly returns of stocks listed on the JSE from 1997-2007 are analysed using mostly the analytic factor and cluster analysis techniques. ... -
miRNAMatcher: High throughput miRNA discovery using regular expressions obtained via a genetic algorithm
(University of the Western Cape, 2008)In summary there currently exist techniques to discover miRNA however both require many calculations to be performed during the identification limiting their use at a genomic level. Machine learning techniques are currently ... -
Molecular dynamic simulation studies of the South African HIV-1 Integrase subtype C protein to understand the structural impact of naturally occurring polymorphisms
(University of the Western Cape, 2021)The viral Integrase (IN) protein is an essential enzyme of all known retroviruses, including HIV-1. It is responsible for the insertion of viral DNA into the human genome. It is known that HIV-1 is highly diverse with a ... -
Molecular dynamic simulation studies of the South African HIV-1 Integrase subtype C protein to understand the structural impact of naturally occurring polymorphisms
(University of Western Cape, 2021)The viral Integrase (IN) protein is an essential enzyme of all known retroviruses, including HIV-1. It is responsible for the insertion of viral DNA into the human genome. It is known that HIV-1 is highly diverse with a ... -
The molecular evolution and epidemiology of Rubella virus
(University of the Western Cape, 2014)Despite widespread rubella virus (RV) vaccination programs, annually RV still causes severe congenital defects in an estimated 100,000 children globally. A concerted attempt to eradicate RV is currently underway and ... -
Molecular modeling and simulation studies to prioritize sequence variants identified by whole-exome sequencing in a South African family with Parkinson's disease
(University of Western Cape, 2021)Parkinson’s disease (PD) is a neurodegenerative disorder that occurs due to a loss of dopaminergic neurons in the substantia nigra. It is one of the most common neurodegenerative disorders, ranking second only to Alzheimer’s ... -
Normalization and statistical methods for crossplatform expression array analysis
(University of the Western Cape, 2012)A large volume of gene expression data exists in public repositories like the NCBI’s Gene Expression Omnibus (GEO) and the EBI’s ArrayExpress and a significant opportunity to re-use data in various combinations for novel ... -
The phylogeography, epidemiology and determinants of Maize streak virus dispersal across Africa and the adjacent Indian Ocean Islands
(University of the Western Cape, 2015)Maize streak disease (MSD), caused by variants of the Maize streak virus (MSV) A strain, is the world's third and Africa’s most important maize foliar disease. Outbreaks of the disease occur frequently and in an erratic ... -
The potential of commercial praziquantel formulations as "off label" treatments for diplectanum oliveri (monogenea) infecting cultured argyrosomus species in the South African marine finfish aquaculture industry
(University of the Western Cape, 2012)Aquaculture is a vast industry all over the world and has increased significantly during the past 30 years. In South Africa, finfish aquaculture farms stretch from Gansbaai to as far as Richards bay with the potential ... -
Reconstruction of gene regulatory networks of inflammation-associated genes in different clinical stages of diffuse large B-cell lymphoma
(University of the Western Cape, 2022)Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy that is driven by complex gene regulatory networks (GRNs). Numerous genes exert distinct effects on the progression and therapeutic outcome of DLBCL. ... -
Regulatory attributes of the carotenoid biosynthetic pathway in Arabidopsis Thaliana under abiotic stress
(University of the Western Cape, 2012)Carotenoids are tetraprenoid (C40) molecules synthesized in plants, fungi, bacteria and algae, via the carotenoid biosynthetic pathway (CBP). Some carotenoids are readily converted to vitamin A (VA) in humans, e.g. ... -
SNP based literature and data retrieval
(University of the Western Cape, 2016)Reference single nucleotide polymorphism (refSNP) identifiers are used to earmark SNPs in the human genome. These identifiers are often found in variant call format (VCF) files. RefSNPs can be useful to include as terms ...