Browsing Magister Scientiae - MSc (Bioinformatics) by Issue Date
Now showing items 1-20 of 44
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HIV subtype C diversity: analysis of the relationship of sequence diversity to proposed epitope locations
(University of the Western Cape, 2002)Southern Africa is facing one of the most serious HIV epidemics. This project contributes to the HIVNET, Network for Prevention Trials cohort for vaccine development. HIVÂ’s biology and rapid mutation rate have made vaccine ... -
HIV Subtype C Diversity: Analysis of the Relationship of Sequence Diversity to Proposed Epitope Locations
(University of the Western Cape, 2002)Southern Africa is facing one of the most serious HIV epidemics. This project contributes to the HIVNET, Network for Prevention Trials cohort for vaccine development. HIV's biology and rapid mutation rate have made vaccine ... -
Analyses of sequence divergence using completely sequenced genomes
(University of the Western Cape, 2003)Using the complete genome, Saccharomyces cerevisiae, which duplicated after its speciation fuom Kluyveromyces lactics, a dataset of 119 putative S. cerevisiae - K. lactis ortholog-pairs was constructed. S. cerevisiae ... -
Assessment of genome visualization tools relevant to HIV genome research: development of a genome browser prototype
(University of the Western Cape, 2004)Over the past two decades of HIV research, effective vaccine candidates have been elusive. Traditionally viral research has been characterized by a gene -by-gene approach, but in the light of the availability of complete ... -
High performance computing and algorithm development: application of dataset development to algorithm parameterization
(University of the Western Cape, 2006)A number of technologies exist that captures data from biological systems. In addition, several computational tools, which aim to organize the data resulting from these technologies, have been created. The ability of these ... -
Market segmentation and factors affecting stock returns on the JSE
(2008)This study examines the relationship between stock returns and market segmentation. Monthly returns of stocks listed on the JSE from 1997-2007 are analysed using mostly the analytic factor and cluster analysis techniques. ... -
miRNAMatcher: High throughput miRNA discovery using regular expressions obtained via a genetic algorithm
(University of the Western Cape, 2008)In summary there currently exist techniques to discover miRNA however both require many calculations to be performed during the identification limiting their use at a genomic level. Machine learning techniques are currently ... -
Computational verification of published human mutations
(University of the Western Cape, 2008)The completion of the Human Genome Project, a remarkable feat by any measure, has provided over three billion bases of reference nucleotides for comparative studies. The next, and perhaps more challenging step is to analyse ... -
An evolutionary genomics approach towards analysis of genes implicated in transmission of trypanosomes between tsetse fly and mammalian host
(2009)Human African trypanosomiasis is the world’s third most important parasitic disease affecting human health after malaria and schistosomiaisis. The world health organization estimates approximately 60 million people at risk ... -
A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
(2009)Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp) parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and Nagana in livestock. Research suggests that tsetse fly ... -
Incidence and regulatory implications of single Nucleotide polymorphisms among established ovarian cancer genes
(University of the Western Cape, 2009)OVARIAN cancer research focuses on answering important questions related to the disease, determining whether new approaches are feasible to contribute towards improving current treatments or discovering new ones. This study ... -
The development of a single nucleotide polymorphism database for forensic identification of specified physical traits
(University of the Western Cape, 2009)Many Single Nucleotide Polymorphisms (SNPs) found in coding or regulatory regions within the human genome lead to phenotypic differences that make prediction of physical appearance, based on genetic analysis, potentially ... -
A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
(University of the western cape, 2009)Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp) parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and Nagana in livestock. Research suggests that tsetse fly ... -
Development and implementation of ontology-based systems for mammalian gene expression profiling
(University of the Western Cape, 2009)The use of ontologies in the mapping of gene expression events provides an effective and comparable method to determine the expression profile of an entire genome across a large collection of experiments derived from ... -
A knowledgebase of stress reponsive gene regulatory elements in arabidopsis Thaliana
(University of the Western Cape, 2011)Stress responsive genes play a key role in shaping the manner in which plants process and respond to environmental stress. Their gene products are linked to DNA transcription and its consequent translation into a response ... -
The identification of biologically important secondary structures in disease-causing RNA viruses
(University of the Western Cape, 2012)Viral genomes consist of either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The viral RNA molecules are responsible for two functions, firstly, their sequences contain the genetic code, which encodes the viral ... -
A computational characterisation of the relationship between genome structure and disease genes
(University of the Western Cape, 2012)This is a pilot study to investigate the relationship between disease gene status and the structure of the human genome with specific reference to regions of recombination. It compares certain characteristics of a control ... -
The potential of commercial praziquantel formulations as "off label" treatments for diplectanum oliveri (monogenea) infecting cultured argyrosomus species in the South African marine finfish aquaculture industry
(University of the Western Cape, 2012)Aquaculture is a vast industry all over the world and has increased significantly during the past 30 years. In South Africa, finfish aquaculture farms stretch from Gansbaai to as far as Richards bay with the potential ... -
The identification of biologically important secondary structures in disease-causing RNA viruses.
(University of the Western Cape, 2012)Viral genomes consist of either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The viral RNA molecules are responsible for two functions, firstly, their sequences contain the genetic code, which encodes the viral ... -
Normalization and statistical methods for crossplatform expression array analysis
(University of the Western Cape, 2012)A large volume of gene expression data exists in public repositories like the NCBI’s Gene Expression Omnibus (GEO) and the EBI’s ArrayExpress and a significant opportunity to re-use data in various combinations for novel ...