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“An investigation into the MicroRNA-gene interactions involved in the pathogenesis of systemic lupus erythematosus”
(University of the Western Cape, 2015)
Systemic lupus erythematosus is a chronic, inflammatory disease characterised by the production of autoantibodies which target particularly the nuclear components of multiple cell types throughout the body. MicroRNA’s have ...
SNP based literature and data retrieval
(University of the Western Cape, 2016)
Reference single nucleotide polymorphism (refSNP) identifiers are used to earmark SNPs in the human genome. These identifiers are often found in variant call format (VCF) files. RefSNPs can be useful to include as terms ...
The phylogeography, epidemiology and determinants of Maize streak virus dispersal across Africa and the adjacent Indian Ocean Islands
(University of the Western Cape, 2015)
Maize streak disease (MSD), caused by variants of the Maize streak virus (MSV) A strain, is the world's third and Africa’s most important maize foliar disease. Outbreaks of the disease occur frequently and in an erratic ...
Integrating regulatory and methylome data for the discovery of clear cell Renal Cell Carcinoma (ccRCC) variants
(University of the Western Cape, 2015)
Kidney cancers, of which clear cell renal cell carcinoma comprises an estimated 70%, have been placed amongst the top ten most common cancers in both males and females. With a mortality rate that exceeds 40%, kidney cancer ...
The identification of biologically important secondary structures in disease-causing RNA viruses
(University of the Western Cape, 2012)
Viral genomes consist of either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The viral RNA molecules are responsible for two functions, firstly, their sequences contain the genetic code, which encodes the viral ...
A computational characterisation of the relationship between genome structure and disease genes
(University of the Western Cape, 2012)
This is a pilot study to investigate the relationship between disease gene status and the structure of the human genome with specific reference to regions of recombination. It compares certain characteristics of a control ...
The molecular evolution and epidemiology of Rubella virus
(University of the Western Cape, 2014)
Despite widespread rubella virus (RV) vaccination programs, annually RV still
causes severe congenital defects in an estimated 100,000 children globally. A
concerted attempt to eradicate RV is currently underway and ...
The potential of commercial praziquantel formulations as "off label" treatments for diplectanum oliveri (monogenea) infecting cultured argyrosomus species in the South African marine finfish aquaculture industry
(University of the Western Cape, 2012)
Aquaculture is a vast industry all over the world and has increased significantly
during the past 30 years. In South Africa, finfish aquaculture farms stretch from
Gansbaai to as far as Richards bay with the potential ...
The identification of biologically important secondary structures in disease-causing RNA viruses.
(University of the Western Cape, 2012)
Viral genomes consist of either deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The viral RNA molecules are responsible for two functions, firstly, their sequences contain the genetic code, which encodes the viral ...
Normalization and statistical methods for crossplatform expression array analysis
(University of the Western Cape, 2012)
A large volume of gene expression data exists in public repositories like the NCBI’s Gene Expression Omnibus (GEO) and the EBI’s ArrayExpress and a significant opportunity to re-use data in various combinations for novel ...