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Evaluation of insertion-deletion polymorphisms with the kit Qiagen Investigator® DIPplex for forensic application in South Africa
(University of the Western Cape, 2015)
Insertion-deletion polymorphisms (indels) have been underutilized in forensic
identification of individuals in comparison with single nucleotide polymorphisms
(SNPs) and short tandem repeat (STRs) systems. The use of ...
Y-STR profiling of four South African populations using the University of the Western Cape 10 locus set
(University of the Western Cape, 2015)
In this study the 10 Y-specific loci of the University of the Western Cape (DYS710, DYS518 385a/b, DYS644, DYS612, DYS626, DYS504, DYS447, DYS447, and DYS481) were analysed in 492 individuals from South African population ...
In vitro investigation of putative interactions between the RING finger domain of Retinoblastoma Binding Protein 6 (RBBP6) and various substrates
(University of the Western Cape, 2015)
Retinoblastoma Binding Protein 6 (RBBP6) is a RING finger-containing protein which plays a critical role in the 3'-end processing of mRNA transcripts. It is a constituent of the human pre-mRNA processing complex but also ...
Development of an actinobacteria based in vitro transcription and translation systems
(University of the Western Cape, 2015)
Heterologous metagenomic screening strategies have relied largely on the construction of DNA libraries and screening in Escherichia coli to access novel enzymes. There is an increased demand for the identification of novel ...
A microbiological and molecular study of campylobacter and related species isolated from ostriches (Struthio camelus)
(University of the Western Cape, 2014)
Campylobacter and related Epsilonproteobacteria (Arcobacter and Helicobacter) are currently viewed as emerging pathogens and are able to cause gastroenteritis, bacteraemia, the Guillain-Barré syndrome, reactive arthritis ...
The isolation and characterisation of novel natural products from marine bacterial symbionts
(University of the Western Cape, 2015)
Drug-resistant infections are a global health crisis and drastically hinder the treatment options to effectively combat disease. Today, natural products remain an important source of novel drug candidates. Micro-organisms, ...
Matrix comparison of isolation conditions for secondary metabolite producing marine sponge associated bacteria
(University of the Western Cape, 2015)
The discovery of novel secondary metabolites has declined significantly in recent years whereas there is a rise in the number of multi-drug resistant pathogens and other types of diseases. The decline in natural product ...
Identification of microRNAs as a class of biomarkers for the early diagnosis of prostate cancer : an in silico and molecular approach
(University of the Western Cape, 2015)
Prostate cancer (PCa) is the second most common form of cancer in men around
the world. In many parts of Africa, data on prostate cancer is sparse. This is
attributed to poor access to testing and diagnostics. The ...
Identification of potential biomarkers in lung cancer as possible diagnostic agents using bioinformatics and molecular approaches
(University of the Western Cape, 2015)
Lung cancer remains the leading cause of cancer deaths worldwide, with the majority of cases attributed to non-small cell lung carcinomas. At the time of diagnosis, a large percentage of patients present with advanced stage ...
Screening for fluorescent and chromoproteins from South African sea anemones
(University of the Western Cape, 2012)
Sea anemones (Order Actinaria) are a diverse order from the Class Anthozoa. They are found in all marine habitats at all depths and their symbiotic relationships play an important role in energy transfers especially in the ...