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Now showing items 11-18 of 18
Marine invertebrate sperm: Assessment of sperm quality using computer-aided sperm analysis
(University of Western Cape, 2020)
Investigating novel aspects of the blood-brain barrier using high resolution electron microscopy
(University of the Western Cape, 2022)
The blood-brain barrier (BBB) is a restrictive interface located between the blood
circulation and the central nervous system (CNS), regulating the homeostatic
environment of the neuronal milieu, by controlling the ...
A retrospective analysis of semen samples and reproductive hormones in Africa and the middle east
(University of Western Cape, 2022)
Semen analysis is the cornerstone for the investigation of male infertility. Semen quality can be influenced by geographical location, age, ejaculatory abstinence, and season. In 2010, the WHO published criteria for human ...
The paracrine effect of normoxic and hypoxic cancer secretions on blood-brain barrier endothelial cells
(University of the Western Cape, 2022)
Cancer is the most common leading cause of death worldwide. Glioblastoma and breast cancer are the most aggressive solid tumour. The survival rate of these tumours depends on their ability to progress and spread. These ...
Sperm function in different human sperm subpopulations
(University of the Western Cape, 2022)
Human semen contains a heterogenous population of spermatozoa of which only a
certain fraction is physiologically suitable for fertilization. Functional characteristics of these
subpopulations and sperm separation ...
The development of targeting nanosystems for the treatment of glioblastoma and neuroblastoma tumours
(University of the Western Cape, 2022)
Chlorotoxin (CTX) peptide selectively targets glioblastoma multiforme (GB) and
neuroblastoma (NB) and has excellent blood-brain barrier permeability. Therefore, CTX is a
promising targeting molecule for nanoparticle (NP) ...
Proteome profiling as tool to determine the effectiveness of traditional Africa therapies for Type 2 diabetes mellitus
(University of the Western Cape, 2022)
Type 2 diabetes mellitus (T2DM) involves multiple organ dysfunction accompanied by a chronic inflammatory state and oxidative stress resulting from a combination of factors such as hyperglycaemia and dyslipidaemia. Although ...
Investigation of the in vitro antidiabetic and neuroprotective effects of selected Helichrysum species against high monosaccharide-induced toxicity
(University of the Western Cape, 2022)
Chronic hyperglycaemia (glucotoxicity), a common complication in diabetes mellitus (DM), is known to cause cognitive decline in some of these patients, often affecting their overall quality of life. Some medicinal plants ...