Browsing South African National Bioinformatics Institute (SANBI) by Author "Tiffin, Nicki"
Now showing items 1-5 of 5
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A computational characterisation of the relationship between genome structure and disease genes
Kibler, Tracey Deborah (University of the Western Cape, 2012)This is a pilot study to investigate the relationship between disease gene status and the structure of the human genome with specific reference to regions of recombination. It compares certain characteristics of a control ... -
Computational genomics approaches for kidney diseases in Africa
Mapiye, Darlington Shingirirai (University of the Western Cape, 2015)End stage renal disease (ESRD), a more severe form of kidney disease, is considered to be a complex trait that may involve multiple processes which work together on a background of a significant genetic susceptibility. ... -
Identification of coding variants associated with familial systemic lupus erythematosus through whole exome sequencing
van Vuuren, Larry Peter (University of the Western Cape, 2016)Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by the production of a wide range of autoantibodies directed against selfantigens. SLE can influence almost any organ system and ... -
Integrating regulatory and methylome data for the discovery of clear cell Renal Cell Carcinoma (ccRCC) variants
Calvert-Joshua, Tracey (University of the Western Cape, 2015)Kidney cancers, of which clear cell renal cell carcinoma comprises an estimated 70%, have been placed amongst the top ten most common cancers in both males and females. With a mortality rate that exceeds 40%, kidney cancer ... -
“An investigation into the MicroRNA-gene interactions involved in the pathogenesis of systemic lupus erythematosus”
Pitts, Stephanie Julia (University of the Western Cape, 2015)Systemic lupus erythematosus is a chronic, inflammatory disease characterised by the production of autoantibodies which target particularly the nuclear components of multiple cell types throughout the body. MicroRNA’s have ...