Browsing Department of Biotechnology by Title
Now showing items 88-107 of 360
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Development of genotyping systems for pharmacogenomics profiling
(University of the Western Cape, 2016)Genetic variability in genes encoding drug metabolizing enzymes, transporters and targets are known to be the main factors of inter-individual differences in therapeutic outcome. Genetic factors are estimated to be responsible ... -
Development of microsatellite (SSR) marker multiplexes for future construction of a genetic linkage map for pear (Pyrus communis L.)
(University of the Western Cape, 2012)Recent advances in the field of plant genetics and application of molecular technologies has lead to greater understanding of various crop genomes and their organization.The applications of these techniques include molecular ... -
The development of nanotechnology-based detection systems for the diagnosis of breast cancer
(University of the Western Cape, 2015)Breast cancer is one of the major causes of death in South Africa. About 1 in 29 South African women are at risk of developing this type of cancer in their lifetime. The global incidence of breast cancer also increases ... -
Development of nanotechnology-based drug delivery and imaging system to the white adipose tissue vasculature using Wistar Rat Model
(University of the Western Cape, 2013)Obesity is a complex metabolic disease of excessive fat accumulation. It is a worldwide epidemic affecting billions of people and its pharmacological management is hampered by drug toxicity and undesirable side effects. ... -
Development of nanotechnology-based therapeutic approaches to treat HIV
(University of the Western Cape, 2012)The rapidly expanding field of nanotechnology has been the focus of many biologists with regard to drug delivery. The ability of nanoparticles to enter cellular compartments makes it possible to explore specific treatment ... -
Development of Y-STR genotyping systems suitable for sexual assault cases in South Africa
(University of the Western Cape, 2010)Sexual assault is a significant problem facing the South African society. In this context, efficient but also affordable genotyping systems are needed for positive identification of criminals in incidences of sexual violence. ... -
Differences in visual attention processing: An event-related potential comparative analysis within psychotic disorders
(University of the Western Cape, 2018)Introduction: Sustained attention is known to be dysfunctional in psychotic disorders. Sustained attention is the ability to remain focused on a specific time-locked stimulus within a task. We aimed to determine whether ... -
Differences in visual attention processing: An event-related potential comparative analysis within psychotic disorders
(University of the Western Cape, 2019)INTRODUCTION: Sustained attention is known to be dysfunctional in psychotic disorders. Sustained attention is the ability to remain focused on a specific time-locked stimulus within a task. We aimed to determine whether ... -
Discovery of biomolecules from South African marine sponge symbionts through Metagenomic studies
(University of the Western Cape, 2018)Marine sponges are known to harbour diverse microorganisms which have been proposed to be involved in the synthesis of most of the natural compounds derived from sponges. However, only about 1% of these microorganisms can ... -
Discriminative eradication of cancer cells using quantum dots functionalised with peptide-directed delivery of a pro-apoptotic peptide
(2013)The therapeutic goal of cancer treatment is to trigger selective cell death in cancer cells. To eliminate cancerous cells effectively, the anti–cancer drugs must be targeted to the affected cells. However, anti–cancer drugs ... -
Diversity of Frankia associated with Morella species of the Cape floristic region of Southern Africa
(University of the Western Cape, 2016)Frankia is one of two partners in the globally distributed N2-fixing actinorhizal symbiosis between this filamentous soil-dwelling actinomycete and almost 300 species of host plants from eight diverse angiosperm families. ... -
The diversity of key anabolic genes in antarctic hypolithons
(2009)Antarctica is known for its pristine environments. A variety of unsuitable environmental conditions were once thought to render the continent unsuitable for sustaining life. However, metagenomic data have revealed a wealth ... -
DNA metabarcoding for the identification of species within vegetarian food samples
(University of the Western Cape, 2021)Aims DNA metabarcoding has recently emerged as a valuable supplementary tool to ensure food authenticity within the global food market. However, it is widely known that highly processed food samples are one of DNA ... -
Domestic greywater systems: a potential reservoir of antibiotic resistance genes transfer
(University of the Western Cape, 2024)During the Western Cape drought from 2015 to 2018, the use of greywater to alleviate pressure on the limited potable water available in the province was encouraged. Greywater, however, has the potential to harbour residual ... -
A dual analysis of the South African Griqua population using ancestry informative mitochondrial DNA and discriminatory short tandem repeats on the Y chromosome
(University of the Western Cape, 2015)The primary objective of this Masters project was to investigate the maternal ancient substructure of the Griqua population in South Africa. Genetic ancestry was determined by investigating ancestry informative single ... -
The effect of blocking selected endocytic mechanisms on heterologous protein secretion in the yeast saccharomyces cerevisiae
(University of the Western Cape, 2018)The yeast Saccharomyces cerevisiae is considered a good host used for heterologous protein production due to the organism’s microbial safety, rapid growth and eukaryotic post- translational processing. As a fermentative ... -
The effect of chitosan in the germination and growth of sorghum bicolor under salt stress
(University of the Western Cape, 2022)The agricultural sector has been facing enormous challenges including reduced crop yield and increased food production demand to cater for the growing population. Crop production is severely affected by abiotic and biotic ... -
Effect of Fusarium oxysporum on the physiological and molecular responses of cowpea plants
(The University of the Western Cape, 2017)Cowpea is a tropical, drought-tolerant legume crop that is indigenous to Africa. The crop is of nutritional importance to both animals and humans as part of their diet. Stress to crop plants is defined as any factor that ... -
Effects of exogenous myristic acid on growth and germination of Brassica napus L. under zirconium toxicity
(University of the Western Cape, 2016)Lipids when exogenously applied are known to cause various changes in ROS levels produced within plants. They can either be beneficial to the plant when not stimulating the overproduction of ROS thus resulting in improved ... -
The effects of gallic acid on the membrane proteome and antioxidant system of wheat plants under salt stress
(University of Western Cape, 2020)Salt stress is a major abiotic stress that accounts for huge agricultural losses worldwide, which in turn threaten food security and sustainable agriculture. Salt triggers the excessive production of reactive oxygen species ...