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In vitro investigation of putative interactions between the RING finger domain of Retinoblastoma Binding Protein 6 (RBBP6) and various substrates
(University of the Western Cape, 2015)
Retinoblastoma Binding Protein 6 (RBBP6) is a RING finger-containing protein which plays a critical role in the 3'-end processing of mRNA transcripts. It is a constituent of the human pre-mRNA processing complex but also ...
In vitro investigation of the ubiquitination and degradation of p53 by Murine Double Minute 2 (MDM2) and Retinoblastoma Binding Protein 6 (RBBP6)
(University of the Western Cape, 2015)
P53 is one of the most important tumour suppressor proteins in the body which protects the cell against the tumourigenic effects of DNA damage by initiating processes such as apoptosis, senescence and cell cycle arrest. ...
Characterisation of N-terminal fragments of Retinoblastoma Binding Protein 6 for structural analysis
(University of the Western Cape, 2016)
Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa RING finger-containing protein that plays a role in 3'-end poly-adenylation of mRNA transcripts as well as acting as an E3 ubiquitin ligase against a number of proteins ...
Investigation of the interactions of retinoblastoma binding protein-6 with transcription factors p53 and Y-Box Binding Protein-1
(2011)
Retinoblastoma Binding Protein 6 (RBBP6) is a 250 kDa multi-domain protein that
has been implicated in diverse cellular processes including apoptosis, mRNA processing and cell cycle regulation. Many of these functions are ...
Solution structure of the RING finger domain from the human splicing-associated protein RBBP6 using heteronuclear Nuclear Magnetic Resonance (NMR) spectroscopy
(2009)
Retinoblastoma-binding protein 6 (RBBP6) is a multi-domain human protein known to play a role in mRNA splicing, cell cycle control and apoptosis. The protein interacts with tumour suppressor proteins p53 and pRb and recent ...
A yeast 2-hybrid screen to identify and characterize interaction partners of the cancer associated protein retinoblastoma binding protein 6
(2009)
Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa protein that is
implicated in mRNA processing and ubiquitination functions and has been
shown to be highly up-regulated in a number of cancers. In humans and mice,RBBP6 ...
Structural characterisation of the interaction between RBBP6 and the multifunctional protein YB-1
(University of the Western Cape, 2010)
As a means of further localising the interaction, truncated fragments derived from the C-terminal region of YB-1, were tested for their interaction with the RING finger domain of RBBP6 using three different assays: a ...
Investigation of the auto-ubiquitination and ubiquitination potentials of Retinoblastoma binding protein 6 and its binding to p53
(University of Western Cape, 2019)
Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa human protein known to play an
essential role in mRNA 3’-end processing, as well as functioning as an E3 ligase to catalyze
ubiquitination and suppression of p53 and ...
Structural characterisation of the interaction between RBBP6 and the multifunctional protein YB-l
(University of the Western Cape, 2010)
Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa RING finger-containing protein whose function is known to be mediated through interaction with other proteins. RBBP6 plays a role in the regulation of the tumour ...