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Comparative analysis of molecular and physiological responses of two canola genotypes to drought stress
(University of the Western Cape, 2016)
Food security has always been one of the priority concerns in Africa, and it is mostly
threatened by drought stress due to climate change. Drought-induced stress is one of the serious limiting factors of plant production, ...
Diversity of Frankia associated with Morella species of the Cape floristic region of Southern Africa
(University of the Western Cape, 2016)
Frankia is one of two partners in the globally distributed N2-fixing actinorhizal symbiosis between this filamentous soil-dwelling actinomycete and almost 300 species of host plants from eight diverse angiosperm families. ...
Screening bacterial symbionts of marine invertebrates for ribosomally synthesized natural products
(University of the Western Cape, 2016)
Pharmaceutical research and development strategies rely on the constant discovery of novel natural products as potential drugs. Recent studies have shown that the
microorganisms associated with sponges are the true producers ...
Development of genotyping systems for pharmacogenomics profiling
(University of the Western Cape, 2016)
Genetic variability in genes encoding drug metabolizing enzymes, transporters and targets are known to be the main factors of inter-individual differences in therapeutic outcome. Genetic factors are estimated to be responsible ...
Bioprospecting for bioactive polysaccharides from marine algae endemic to South Africa
(University of the Western Cape, 2016)
Fucoidan is a marine-derived sulphated polysaccharide with bioactive properties ideal for the food, chemical and pharmaceutical industries. The polysaccharide consists largely of L-fucose, has a highly heterogeneous structure ...
Proteome signature of breast cancer cells treated with fucoidan
(University of the Western Cape, 2016)
Breast cancer is responsible for a large portion of cancer-related deaths. Worldwide, incidence is increasing. Routinely-used treatments for breast cancer are invasive and are associated with a range of side-effects which ...
Modulation of brassica rapa L. antioxidant activities by exogenous methylglyoxal under zirconium stress
(University of the Western Cape, 2016)
With a decrease in water availability and arable land, and the ever-increasing reports of toxic chemical pollutants, it is crucial to elucidate plants’ mechanisms of adaptability to these abiotic stressors. South Africa ...
A forensic analysis of genetic variation in the Botswana population
(University of the Western cape, 2016)
This thesis has been placed under a long term embargo. Forensic and population genetic parameters were investigated in the Botswana population using autosomal and Y-chromosome short tandem repeat markers. AmpFlSTR Profiler ...
Characterisation of N-terminal fragments of Retinoblastoma Binding Protein 6 for structural analysis
(University of the Western Cape, 2016)
Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa RING finger-containing protein that plays a role in 3'-end poly-adenylation of mRNA transcripts as well as acting as an E3 ubiquitin ligase against a number of proteins ...
In-silico optimization and molecular validation of putative anti-HIV antimicrobial peptides for therapeutic purpose
(University of the Western cape, 2016)
AIDS is considered a pandemic causing millions of deaths worldwide and a cure for this disease is still not available. Failure to implement early treatments due to the poor diagnostic
methods and ineffective therapeutic ...