Department of Biotechnology: Recent submissions
Now showing items 81-100 of 368
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Investigation of the auto-ubiquitination and ubiquitination potentials of Retinoblastoma binding protein 6 and its binding to p53
(University of Western Cape, 2019)Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa human protein known to play an essential role in mRNA 3’-end processing, as well as functioning as an E3 ligase to catalyze ubiquitination and suppression of p53 and ... -
Investigation of protein-protein interactions involving Retinoblastoma Binding Protein 6 using immunoprecipitation and Nuclear Magnetic Resonance Spectroscopy
(University of the Western Cape, 2019)Retinoblastoma Binding Protein 6 (RBBP6) is a 200 KDa multi-domain protein that has been shown to play a role in mRNA processing, cell cycle arrest and apoptosis. RBBP6 interacts with tumour suppressor proteins such as ... -
Isolation and characterization of plant growth promoting endophytic bacteria from Medicago lupulina for enhanced drought tolerance in Maize
(University of the Western Cape, 2019)Maize is one of the major staple foods in many African nations however, this crop is sensitive to environmental stressors. Drought is a major environmental stressor affecting maize production. Due to global warming, drought ... -
Marine bacteria as a potential source for novel antimicrobial compounds
(University of the Western Cape, 2020)The high rate of rediscovery of known compounds has led to a decline in the discovery of novel natural products. The high biodiversity of organisms growing in extreme conditions such as oceans has led to the increased ... -
Antimicrobial, anticancer and catalytic activities of green synthesized Avocado seed extract-gold nanoparticles
(University of the Western Cape, 2019)Nature through billions of years of trial and error has produced an immeasurable amount of natural systems like plants, birds and animals. The intelligence of nature is hidden in these natural systems and researchers are ... -
De novo assembly of the rooibos genome
(University of Western Cape, 2020)Rooibos (Aspalathus linearis) is endemic to the Cederberg region of South Africa, and one of the few indigenous medicinal plants commercially cultivated in the country. International interest in rooibos is growing, and ... -
Nanoformulation of Artemisia afra and its potential biomedical applications in type 2 diabetes
(University of Western Cape, 2019)Current research classifies Type 2 diabetes as most prevalent non-communicable diseases in South Africa. Approximately 285 million people are affected globally with an expected increase to 595 million by the year 2035. ... -
Physiological and molecular characterization of wheat cultivars to Fusarium oxysporum infection
(University of the Western Cape, 2019)Biotic stress is one of the main causes for agricultural loss of economically important cereal crops. The increasing prevalence of biotic stress inflicted by fungal species such as Fusarium has significantly reduced yields ... -
Silica Coated Core-Shell Quantum Dot-based Electro-Immunosensor for Interferon Gamma TB Disease Biomarker
(University of the Western Cape, 2020)Tuberculosis (TB) is a disease that results from infection by Mycobacterium tuberculosis, which is regarded the most common infecting organism. TB has killed countless numbers of people particularly in underdeveloped ... -
Physio-biochemical characterization of two wheat cultivars to Fusarium proliferatum infection
(University of the Western Cape, 2019)Wheat is a key global commodity in terms of acreage and tradeable value and as a staple in household diets. Many factors including biotic stress conditions have detrimental effects on global wheat production and yield. ... -
Evaluation of agronomic and drought response traits in two cultivars of soybean for cultivation in the Transkei region of the Eastern Cape
(University of Western Cape, 2020)Drought is a major stress that affects the productivity of plants across the globe. The consequences of drought are posed to continue reducing agricultural productivity as world climate changes. This makes it imperative ... -
Identification and Molecular validation of Biomarkers for the accurate and sensitive diagnosis of bacterial and viral Pneumonia
(University of Western Cape, 2019)Pneumonia remains the major cause of death in children and the elderly and several efforts have been intensified to reduce the rate of pneumonia infection. The major breakthrough has been the discovery of certain biomarkers ... -
Characterization and engineering of Bacillus megaterium AS-35, for use in biodegradation of processed olive wastewater
(University of Western Cape, 2005)The popularization and health benefits associated with the "Mediterranean diet" saw a world wide increase in the production and consumption of processed olives and olive oil. During the brining of table olives large ... -
Genetic analysis of mitochondrial DNA within Southern African populations.
(UWC, 2020)As human beings we are curious about our origin and ancestry. A curiosity has led to an investigation of human evolution and expansion across the world by means of population genetics and phylo-genetics by evaluating a ... -
Methylgyoxal signalling in Phaseolus vulgaris under phosphate deficiency
(UWC, 2020)In this study, we observed that phosphate (P) deficiency stunted plant growth and produced plants with poor morphological characteristics (yellow and small leaves). Furthermore, we treated plants with 0.8 mM (control) and ... -
Characterization of ATP-binding cassette drug transporters and their role in breast cancer treatment using in silico approach
(University of the Western Cape, 2019)Breast cancer is the most common cancer in women worldwide, and is the second most common cancer in the world, responsible for more than 500 000 deaths annually. Estimates are that 1 in 8 women will develop breast cancer ... -
Green synthesis and characterization of silver nanoparticles (AgNPs) from Bulbine frutescens leaf extract and their antimicrobial effects
(University of the Western Cape, 2020)Combating antimicrobial resistant infections caused by nosocomial pathogens poses a major public health problem globally. The widespread use of broad-spectrum antibiotics for the treatment of wound infections has led to ... -
Development and validation of a pharmacogenomics profiling panel suitable for personalizing Metformin therapy
(University of the Western Cape, 2019)The burden of non-communicable diseases (NCDs) in South Africa is predicted to increase substantially in the next decades if the necessary preventative measures are not taken. The two most common NCDs associated with rapid ... -
Isolation and characterization of stem endophytic bacteria from weed plants for enhancing Vanadium tolerance in Brassica napus
(University of the Western Cape, 2019)Bacterial endophytes are able to improve the growth of their hosts through a number of different mechanisms such as nutrient uptake regulation, plant hormone production and regulation, siderophore production and phosphate ... -
Proteomic and functional characterisation of biofilm formation in Xylophilus ampelinus
(University of the Western Cape, 2019)Xylophilus ampelinus, the causal agent of bacterial blight of grapevine, inhabits the vascular tissues of infected plants where the cells appear to form assemblages resembling biofilms. Bacterial blight of grapevine ...