Browsing Philosophiae Doctor - PhD (Medical BioScience) by Title
Now showing items 38-57 of 71
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Marine invertebrate sperm: Assessment of sperm quality using computer-aided sperm analysis
(University of Western Cape, 2020) -
Medicinal uses of Galenia africana: A study of the antimicrobial, antifungal and anticancer properties
(University of the Western Cape, 2017)Over the years, microorganisms have become resistant to commonly used antimicrobial agents leading to multidrug resistance. This is believed to occur even with new classes of therapeutic agents thus creating a challenge ... -
Modulation of colon carcinogenesis by dietary ω-6/ω-3 fatty acid ratios : a chemopreventive strategy?
(University of the Western Cape, 2015)The aim of this study was to determine whether dietary fats constituting specific ω-6/ω-3 fatty acids (FA) ratio has chemopreventive modulating effects on the development of colon cancer. Western diets intake of saturated ... -
A molecular investigation of the prevalence of suspected periodontopathogens and their association with preterm birth
(University of the Western Cape, 2010)More than 20 million infants in the world (15.5 % of all births) are born with low birth weight. Ninety-five % of them are in developing countries. oral colonization of gram-negative anaerobes has been implicated as a risk ... -
''A molecular investigation of the prevalence of suspected periodontopathogens and their association with preterm birth.''
(University of the Western Cape, 2010)More than 20 million infants in the world (15.5 % of all births) are born with low birth weight. Ninety-five oZ of them are in developing countries. Oral colonization of Gramnegative anaerobes has been implicated as a risk ... -
Optimizing embryo culture conditions and spent culture media analysis as predictors of embryo quality and pregnancy
(University of the Western Cape, 2021)The aim of this thesis is first, to evaluate various culture conditions to improve embryo development, and secondly, to analyze spent culture media for any biomarkers that may be predictive of embryo health. Single-step ... -
The paracrine effect of normoxic and hypoxic cancer secretions on blood-brain barrier endothelial cells
(University of the Western Cape, 2022)Cancer is the most common leading cause of death worldwide. Glioblastoma and breast cancer are the most aggressive solid tumour. The survival rate of these tumours depends on their ability to progress and spread. These ... -
Phenotypic and molecular characteristics of Methicillin-resistant Staphylococcus Aureus isolates from stored patient samples in Misurata hospitals and poultry from commercial markets, Libya
(University of the Western Cape, 2019)The emergence of virulent and drug-resistant bacterial strains such as methicillin-resistant Staphylococcus aureus (MRSA) is a global public health burden. The World Health Organization (WHO) has placed MRSA and ... -
Phylogeography and speciation in the genus arthroleptella
(2009)Moss frogs are restricted to permanently moist terrestrial habitats in the south-western Cape Fold Mountains. There is a very close association between Arthroleptella distribution and Table Mountain Sandstone. Suitable ... -
Potamanautes warreni biomarker assays to monitor silver nanomaterial contaminants in aquatic environments
(University of the Western Cape, 2016)There has been extensive growth in nanoscale technology in the last few decades to such a degree that nanomaterials (NMs) have become a constituent in a wide range of manufactured commercial and domestic products. This ... -
Potential anti-melanogenic effects of selected South African plants on b16 melanoma cells
(University of the Western Cape, 2019)Dyspigmentation is one of the commonest dermatological presenting complaints from patients, particularly hyperpigmentation. Hyperpigmentation can cause dangerous psychological and emotional impact on self-perception and ... -
Premature aging of the lungs of the offspring induced by maternal nicotine exposure during gestation and lactation: protective effects of tomato juice
(University of the Western Cape, 2012)exposed to nicotine through the blood and the milk of the mother. Nicotine is thus expected to interact with the developing fetus and the offspring of mothers who smoke or use NRT for smoking cessation, resulting in the ... -
Protein expression and antifungal effect of fluconazole-resistant Candida species following effective in vitro treatment with K21, a novel antifungal agent
(University of Western Cape, 2019)Background: Oropharyngeal candidiasis, caused by the fungus Candida, is the most common opportunistic infection affecting the quality of life of immunocompromised patients. Fluconazole is widely used as the first line ... -
Proteome profiling as tool to determine the effectiveness of traditional Africa therapies for Type 2 diabetes mellitus
(University of the Western Cape, 2022)Type 2 diabetes mellitus (T2DM) involves multiple organ dysfunction accompanied by a chronic inflammatory state and oxidative stress resulting from a combination of factors such as hyperglycaemia and dyslipidaemia. Although ... -
Radiation-induced Leukaemia in South Africa: Response of lymphocytes and cd34+ cells to different radiation qualities
(University of the Western Cape, 2020)Epidemiological studies have highlighted that leukaemia can be considered as the most prominent malignancy after radiation exposure during childhood. The lifetime risk on radiation-induced leukaemia for a given dose is 3 ... -
Radiation-induced leukaemia in South Africa: response of lymphocytes and cd34+ cells to different radiation qualities.
(University of the Western Cape, 2020)Epidemiological studies have highlighted that leukaemia can be considered as the most prominent malignancy after radiation exposure during childhood. The lifetime risk on radiation-induced leukaemia for a given dose is 3 ... -
The relationship between "fertilizaiton environment" and structure and physiology of selected Anuran Spermatozoa
(University of the Western Cape, 1993)The propagation of species and modes of fertilization of higher vertebrates are aspects which have been extensively researched. Studies on the spermatology of lower vertebrates have not received the same attention. Anurans ... -
A retrospective analysis of semen samples and reproductive hormones in Africa and the middle east
(University of Western Cape, 2022)Semen analysis is the cornerstone for the investigation of male infertility. Semen quality can be influenced by geographical location, age, ejaculatory abstinence, and season. In 2010, the WHO published criteria for human ... -
The role of high-risk human papillomavirus in periocular cancers
(University of the Western Cape, 2018)PURPOSE: High risk human papillomavirus (HR-HPV) is well established as a causative agent of squamous cell carcinoma (SCC) of the orophaynx. HR-HPV has also been reported in periocular cancers and precancers, but controversy ... -
The role of high-risk human papillomavirus in periocular cancers
(University of the Western Cape, 2018)Purpose: High risk human papillomavirus (HR-HPV) is well established as a causative agent of squamous cell carcinoma (SCC) of the orophaynx. HR-HPV has also been reported in periocular cancers and precancers, but controversy ...
