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Discovery of anti-mycobacterial natural products from South African marine algae
(University of the Western Cape, 2019)
Tuberculosis is a communicable disease which affects millions of people around the world.
Although the case reports are declining, the eradication rate of this disease is far too slow.
Natural products have played a key ...
Novel adamantane-chloroquinolin conjugates to overcome plasmodium falciparum chloroquine resistance
(University of the Western Cape, 2017)
Malaria poses devastating health and socioeconomic outcomes on global health especially
among pregnant women and children below the age of 5 in endemic areas. This is
exacerbated by Plasmodium falciparum resistance to ...
Biosimilar’s Growth in Pharmerging Markets: An Analysis of the Regulatory Environments
(University of the Western Cape, 2020)
The introduction of biosimilars to health care markets across the globe has had some success
in increasing competition and improving the cost of healthcare. While savings are important
for driving the biosimilar uptake, ...
Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
(University of the Western Cape, 2020)
Malaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are ...
Chalcone and curcumin hybrids of indole propargylamines as multifunctional neuroprotective agents
(University of the Western Cape, 2020)
Neurodegenerative disorders (NDs) are a range of chronic brain disorders that includes
amongst others motor function loss. Parkinson’s disease (PD) is one of the common NDs that
has an insidious onset and diagnosed when ...
Investigating the Perception of the Influence of Pharmaceutical Marketing on Pharmacists and Doctors Dispensing and Prescribing Practices.
(University of the Western Cape, 2021)
Pharmaceutical marketing via a wide range of promotional tools to doctors and pharmacists is
one of the primary methods used by the pharmaceutical industry to drive product sales.
Pharmaceutical representatives are the ...
Synthesis and evaluation of 7-substituted 3-propargylamine coumarin derivatives as multifunctional monoamine oxidase and cholinesterase inhibitors for Alzheimer’s Disease treatme
(University of Western Cape, 2020)
Alzheimer’s Disease (AD) is a neurodegenerative disease which results from the irreversible loss of neurons in the brain. The disease is characterized by progressive cognitive impairment with recurrent short-term memory ...
Evaluation of the effect of polyethylene glycol incorporation on the performance of poly(lactic-co-glycolic acid) nanoparticles
(University of the Western Cape, 2016)
Nanoparticle drug delivery is challenged by the binding of proteins in
blood which result in their rapid removal from the circulatory system. Nanoparticles
engineered to delay protein binding have shown to have extended ...
Active encapsulation of diclofenac sodium into liposomes for ophthalmic preparations
(University of the Western Cape, 2018)
Liposomes as a drug carrier in the pharmaceutical industry has gained currency since its
discovery in 1965 by Bangham A. D. Liposomes have been shown to improve bioavailability
as they can be delivered to target sites ...
Post-market assessment of the quality of first line regimen fixed-dose combination antiretrovirals in South Africa
(University of the Western Cape, 2017)
The rapid increase in access to new antiretrovirals (ARVs) worldwide and, especially in sub-Saharan Africa, coupled with the well-documented problem of poor quality ARVs in developing countries has underscored the need for ...