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Now showing items 221-229 of 229
An electrophysiological exploration into the Sertoli cell, utilizing plant extracts with a view to contraception
(University of the western cape, 2003)
Certa in medicinal plant extracts have been shown to have a contraceptive effect on male rats (Rajasekaran et al. , 1988) and mice (Kong et al., 1986). A possible site for the mechanism of action has been identified as the ...
The effects of doxorubicin loaded chitosan-alginate nanoparticles on SK-N-BE(2) neuroblastoma cells
(University of the Western Cape, 2022)
Cancer is a life-threatening disease and one of the leading causes of death globally. Cancer was thought to be associated with developed countries only but it is increasingly becoming a major health challenge in developing ...
Investigations on the antifungal and cancer modulating properties of extracts from selected species of Tulbaghia
(University of the Western Cape, 2012)
Fusarium verticil/ioides (Sacc) Nirenberg a common phytopathogen of maize and maize-based products produces fumonisin B (FB) mycotoxins that have been related to several diseases such as equine leukoencephalomalacia (ELEM), ...
The screening of phyto-pesticides for potential adverse effects on human health
(University of the Western Cape, 2010)
Pesticides are designed to control or eliminate pests such as insects, rodents, weeds, bacteria, and fungi. They are used at a global scale for agricultural produce. Although pesticides playa significant role in increasing ...
An evaluation of the biopesticidal characteristics of Helichrysum marifolium and Helichrysum patulum and their effects on animal metabolism
(University of the Western Cape, 2002)
There are a number of pesticides that are suspected to be endocrine disrupters Many of these pesticides are man-made. Endocrine disrupters are chemicals that can lead to an increase in birth defects, sexual abnormalities, ...
In vitro neuroprotective potential of phyllanthin in MPP+- induced toxicity in SH-SY5Y neuroblastoma cells
(University of the Western Cape, 2023)
Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s disease, with an estimated 9 million people projected to be affected worldwide by the year 2030. PD is associated ...
Dexamethasone's impact on LPS-induced inflammation of blood-brain barrier endothelial cells
(University of the Western Cape, 2023)
The blood-brain barrier (BBB) serves as a protective and regulatory barrier between the blood and the brain. Microvascular endothelial cells provide homeostatic regulation of the central nervous system (CNS). BBB integrity ...
The effect of doxorubicin encapsulated chitosan alginate nanoparticles and curcumin on multidrug resistant colon cancer cell lines
(University of the Western Cape, 2024)
Purpose: Although chemotherapeutic drugs have improved the survival rate of patients diagnosed with colorectal cancer, resistance to chemotherapy frequently leads to therapeutic failure and poor patient outcomes. Multidrug ...
The phenomenon of skin lightening among young adults, and the effect of selected plant extracts on tyrosinase and melanogenesis activity
(University of the Western Cape, 2023)
Skin lightening practice refers to the use of skin lightening products to achieve a fairer skin complexion. This is common practice among people of several Asian, North American, South American countries. On the African ...