Magister Scientiae - MSc (Medical BioSciences): Recent submissions
Now showing items 61-80 of 160
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The effect of nigella sativa oil on male reproductive function in male Wistar rats exposed to an obesogenic diet
(University of Western Cape, 2020)Obesity is a growing public health concern globally, particularly in developed countries such as the United States (US). More than 30% of Americans are considered obese. In the past 20 years in America, incidence of ... -
Screening of Selected Libyan Medicinal Plants for the Synthesis of Metal Nanoparticles and their activity against Streptococcus mutans
(University of the Western Cape, 2020)Nanotechnology has emerged as an elementary division of modern science and stemmed directly from green chemistry twelve basic concepts, it receives global attention due to its unique character and ample applications. It ... -
The Assessment of Effects of Carbon Quantum Dots on Immune System Biomarkers Using RAW 264.7 Macrophage Cells
(University of the Western Cape, 2020)Nanotechnology is a rapidly growing field of research. Due to major innovations brought about by developments in nanotech, several consumer products are currently available containing nanomaterials. The increase of ... -
The identification of novel biomarkers in response to pollutant exposure using proteome profiler arrays
(University of Western Cape, 2020)Nanotechnology is a rapidly expanding field with a multitude of practical uses namely textiles, cosmetics, agriculture, and health sciences. The focus, for the purposes of this thesis, will be on carbon dots. The small ... -
The potential therapeutic role of palm oil on prostate cancer
(University of the Western Cape, 2020)Prostate cancer is one of the heterogeneous groups of neoplastic diseases originating from the reproductive system of the male naming, the prostate gland. In the west, prostate cancer is the most common cancer affecting ... -
Evaluation of sperm functionality in non-human primates, focussing on sperm capacitation
(University of the Western Cape, 2019)The incidence of male infertility is increasing, with up to 50% of infertile males having “unexplained” (idiopathic) infertility. Newly developed molecular techniques have great value in detecting subtle causes of male ... -
Effects of graphene oxide nanoparticles on the immune system biomarkers produced by RAW 264.7
(University of the Western Cape, 2019)Graphene oxide (GO) is a single carbon layer, oxygen bearing graphene derivative, containing hydroxyl and carboxyl groups. Graphene oxide nanoparticles (GONPs) are promising nanomaterials for a variety of applications such ... -
Mercury leaching from dental amalgam fillings and its association with urinary zinc
(University of the Western Cape, 2019)Mercury (Hg) is an example of a toxic metal that is not essential for nutrition. It exists in organic and inorganic forms in seafood and vapour from dental amalgam fillings respectively. Elemental mercury (Hg0) from dental ... -
Seasonal differences in semen characteristics and sperm functionality in Tankwa goats
(University of the Western Cape, 2018)Tankwa goats have been free-ranging in the Tankwa Karoo National Park in the Northern Cape for more than 80 years. A genetic study concluded that these feral goats are a unique genetic resource compared to other goat breeds ... -
Evaluating the neuroprotective effects of fermented rooibos herbal tea in Wistar rats exposed to bisphenol-A during gestation and lactation
(University of the Western Cape, 2019)Exposure to endocrine-disrupting chemicals as bisphenol A (BPA) during gestation and early postnatal life is known to disrupt normal developmental processes and alter the body’s endocrine system leading to deleterious ... -
The effect of methamphetamine on the blood-testis barrier
(University of the Western Cape, 2018)Introduction The blood-testis barrier (BTB) is formed by tight junctions between adjacent Sertoli cells. The barrier formed by these tight junction helps to create a specialized environment for spermatogenesis and provide ... -
The association of mercury from dental amalgam with urinary selenium
(University of the Western Cape, 2017)Background: Dental amalgam has been the traditional material for filling cavities in teeth. Mercury (Hg) is a component of dental amalgam, from where it is continuously released and deposited in different tissues, mostly ... -
Medicinal uses of Galenia africana: A study of the antimicrobial, antifungal and anticancer properties
(University of the Western Cape, 2018)Medicinal uses of Galenia africana: A study of the antimicrobial, antifungal and anticancer properties Over the years, microorganisms have become resistant to commonly used antimicrobial agents leading to multidrug resistance. ... -
The potential neuroprotective effects of two South African plant extracts in hydrogen peroxide-induced neuronal toxicity
(University of the Western Cape, 2018)Background: Oxidative stress induced by reactive oxygen species has been strongly associated with many neurodegenerative diseases (NDDs) and many medicinal plant-derived products have been reported to exert potent antioxidant ... -
Radioprotective effects of rooibos herbal tea on the developing central nervous system of wistar rats
(University of the Western Cape, 2018)Background: Early postnatal radiation exposure from environmental, diagnostic or therapeutic sources is potentially deleterious to the developing nervous system resulting in oxidative stress, structural damage, altered ... -
Formulation and evaluation of the biocompatibility of chitosan-dextran nanoparticles using a blood-brain barrier model
(University of the Western Cape, 2018)Central nervous system (CNS) infections are a therapeutic challenge. This is partly due to insufficient drug penetration across the blood-brain barrier (BBB). The BBB is a specialized, highly selective, metabolically active ... -
The role of arylamine N-acetyltransferase 1 (NAT1) in the clinical therapy of tuberculosis
(University of the Western Cape, 2017)Despite attempts to develop new drugs to reduce the worldwide mortality rate attributable to tuberculosis (TB), the illness remains a threat. Isoniazid (INH) has been used as a frontline drug for decades. However, several ... -
The effect of rooibos and green tea flavnoids on the physiology of TM3 Leydig cells
(University of the Western Cape, 2018)Camellia sinensis (C.sinesis) and Aspalathus linearis (A.linearis) are popular beverages consumed in many countries. Consumption of these plants may protect against cardiovascular disease, neurodegenerative disease, various ... -
The use of whole blood cell cultures as a model for assessing the effects of SeptilinTM on the immune system.
(University of the Western Cape, 2017)In the past three decades there has been a huge increase in the use of herbal medicine globally. The active principles of these herbal medicines are mostly unknown with supportive evidence for safety and efficacy very ... -
The effects of selective inhibitors of n-glycosylation and endoplasmic reticulum stress inducers on the expression of neuroblastoma drug resistance
(University of the Western Cape, 2017)Neuroblastoma (NB) represents 8-10% of all childhood tumours and accounts for approximately 15% of all cancer-related deaths in the paediatric population. Approximately half of newly diagnosed children with this tumour ...