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dc.contributor.advisorOnani, Martin
dc.contributor.authorCwasi, Phelisa
dc.date.accessioned2023-07-13T14:07:18Z
dc.date.available2023-07-13T14:07:18Z
dc.date.issued2023
dc.identifier.urihttp://hdl.handle.net/11394/10390
dc.description>Magister Scientiae - MScen_US
dc.description.abstractMetal-based drugs are preferred motifs that serve as major pharmacophores in bioactive compounds for a variety of diseases, including as tuberculosis (TB). Heterocyclic, Schiff bases, aliphatic amines and other ligands are among the many potential scaffolds in drug design. To contribute to the development of these drugs, we discovered the metal-based organometallic complexes that could potentially be effective against tuberculosis, which is a common bacterial infectious disease that is caused by the bacillus mycobacterium tuberculosis (Mtb). As the demand for new compounds with desired antibacterial properties has grown over the past few decades, interest in Schiff bases has also significantly increased. Thus, in this study, five Schiff base ligands namely {HL1 = (Z)-4-chloro-2-((phenylimino)methyl)phenol, HL2 = (Z)-4-chloro-2-((o-tolylimino)methyl)phenol, HL3 = (Z)-4-chloro-2-((ptolylimino) methyl)phenol, HL4 = (Z)-4-chloro-2-(((2,4- dimethylphenyl)limino)methyl)phenol and HL5 = (Z)-4-chloro-2-(((2,6- dimethylphenyl)limino)methyl)phenol} were synthesized and fully characterized and complexed with CuCl2 for the synthesis of copper (II) salicylaldimine compounds.en_US
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.subjectBioactive compoundsen_US
dc.subjectTuberculosisen_US
dc.subjectBacterial infectious diseaseen_US
dc.subjectSalicylaldimine compoundsen_US
dc.titleOrganometallic improvement of some tuberculosis drugsen_US
dc.rights.holderUniversity of the Western Capeen_US


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