Browsing School of Pharmacy by Author "Malan, Sarel F."
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Synthesis & biological evaluation of neuroprotective molecules with polycyclic scaffolds
Sharma, Rajan (University of the Western Cape, 2017)Among neurological disorders, many of the most devastating disorders are neurodegenerative. Modern research associates excitotoxicity to a variety of neuropathological conditions, suggesting that the neurodegenerative ... -
Tacrine, trolox and tryptoline as lead compounds for the design and synthesis of multi-target drugs for Alzheimer's disease therapy
Teponnou, Gerard A. Kenfack (University of the Western Cape, 2016)The cascade of neurotoxic events involved in the pathogenesis of Alzheimer's disease may explain the inefficacy of currently available treatment based on acetylcholinesterase inhibitors (AChEI - donepezil, galantamine, ...