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Now showing items 11-20 of 27
Ethionamide pharmacokinetics in multidrugresistant tuberculosis patients with and without HIVinfection
(University of the Western Cape, 2017)
Many studies have investigated the pharmacokinetics (PK) of anti-tuberculosis drugs
in tuberculosis patients. However, currently in South Africa, no studies have been
done on ethionamide (ETH) PK in adult MDR-TB patients ...
Preparation, characterisation and evaluation of Artemisia afra phytosomes with modified release properties
(University of the Western Cape, 2017)
Dissolution studies on various dosage forms (powder, tablets, teabags and alginate beads) of
the Artemisia afra freeze dried aqueous extract (FDAE) all exhibit a rapid release profile.
Generally, such a release profile may ...
A Comprehensive Study on the Global Regulatory Requirements for the submission of a Post-Approval Change, specifically a Change in Manufacturing Site
(University of the Western Cape, 2017)
Regulatory requirements for post-approval changes vary for different countries around
the world. It is a challenging and costly process for pharmaceutical companies to
manage changes to the approved regulatory dossier over ...
Knowledge-based integration of Zimbabwean traditional medicines into the National Healthcare System: A case study of prostate cancer
(University of the Western Cape, 2017)
This study sought to identify the bottlenecks in the promotion of Zimbabwean Traditional Medicines (ZTMs) towards improving the national healthcare delivery system. The indigenous medicines lost value and recognition to ...
Investigating the Economic Impact of Mandatory Electronic Prescribing Requirements in the United States
(University of the Western Cape, 2017)
Technological advancements applied to healthcare may holistically improve the economic
burden of prescription medication costs. United States legislative actions requiring utilization of
electronic prescribing (e-prescribing) ...
Novel adamantane-chloroquinolin conjugates to overcome plasmodium falciparum chloroquine resistance
(University of the Western Cape, 2017)
Malaria poses devastating health and socioeconomic outcomes on global health especially
among pregnant women and children below the age of 5 in endemic areas. This is
exacerbated by Plasmodium falciparum resistance to ...
Development of a model to predict the cost of treatment of breast cancer with chemotherapy at Groote Schuur hospital
(University of the Western Cape, 2017)
In South Africa, breast cancer dominates other forms of cancer affecting women in
both prevalence and mortality rates according to the National Cancer Registry. The
incidence and cost of breast cancer have been on the rise ...
Innovator Medicines Versus Generic Medicine Package Inserts Safety Amendments, the Reality in South Africa
(University of the Western Cape, 2017)
Availability of clinically relevant and unbiased medicine information goes a long way in
promoting rational use of medicines. The package insert (PI) is one of the sources of
information utilised by healthcare professionals ...
A Community Pharmacy perspective on the epidemiology of antimicrobial drugs in the Kuilsriver urban area
(University of the Western Cape, 2017)
The epidemiology of drugs is 'defined as the manner in which drugs are used by doctors,
nurses, pharmacists and patients. As such epidemiology of antimicrobial drugs is the manner
in which this class of drugs is used by ...
Synthesis & biological evaluation of neuroprotective molecules with polycyclic scaffolds
(University of the Western Cape, 2017)
Among neurological disorders, many of the most devastating disorders are
neurodegenerative. Modern research associates excitotoxicity to a variety of
neuropathological conditions, suggesting that the neurodegenerative ...