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Phytochemical and biological studies of Helichrysum cymosum
(University of the Western Cape, 2020)
Diabetes mellitus (DM) is well known as a group of systemic metabolic disorders with a considerable mortality rate around the world. Hyperglycemia is the main consequence of DM, which results from the shortage in insulin ...
Risk based approach of post- approval changes in central America and Dominican republic, identifying opportunities for convergence with EMA and FDA
(University of Western Cape, 2021)
In Central American countries (Guatemala, El Salvador, Honduras, Nicaragua,
Costa Rica and Panama) and Dominican Republic (DR) the approval timelines for major changes
are described ranging from 12 to 18 months, these ...
Cheminformatic Approaches to Hit-Prioritization and Target Prediction of Potential Anti-MRSA Natural Products
(University of the Western Cape, 2020)
The growing resistance of Methicillin-Resistant Staphylococcus aureus (MRSA) to currently prescribed drugs has resulted in the failure of prevention and treatment of different infections caused by the superbug. Therefore, ...
Mobile phone applications targeted towards medicine adherence in Africa: A systematic review
(University of Western Cape, 2020)
According to the WHO (2017), non-communicable diseases (NCDs) which include
stroke, cancer, heart disease, chronic respiratory disease and diabetes is the leading
cause of death and is responsible for seventy one percent ...
Design and synthesis of new scaffolds as antiproliferative agents and potential hsp90 inhibitors
(University of Western Cape, 2020)
Natural products have been an important source of drugs and novel lead compounds in drug
discovery. Their unique scaffolds have led to the synthesis of derivatives that continue to give rise
to medicinally relevant agents. ...
Ongoing development of guidelines for biosimilar medicines assessment in Uganda: Critical evaluation and recommendations for inclusion
(University of Western Cape, 2020)
A Biosimilar is defined as a biologic product that is similar but not identical to the reference/originator biologic product. Biologic products have raised hopes of improving the quality of life especially in the treatment ...
The physicochemical characterisation, compatibility testing and solid-state form screening of terizidone - Pyridoxine combinations
(University of Western Cape, 2021)
Terizidone (TZD) is considered an essential anti-tuberculosis drug and in South
Africa it is prescribed as part of the multi-drug resistant tuberculosis (MDR-TB) treatment
regimen. From a literature study it became ...
Novel norbornane derivatives as potential neuroprotective agents
(University of Western Cape, 2020)
Neurodegenerative disorders are characterised by progressive loss of the brain’s physiological
functions as a result of gradual degeneration of neurons in the central nervous system. Even
though they are classified as ...
Exploration of the training/educational background and the roles of regulatory affairs associates/officers in selected South African based pharmaceutical companies in Gauteng province
(University of Western Cape, 2021)
Regulatory Affairs (RA), within the pharmaceutical business, could be a profession that covers different registration parameters of a pharmaceutical product. This is a profession that was developed to protect the public ...
Use and consumer perceptions of dietary supplements in the fitness community of Gaborone, Botswana
(University of Western Cape, 2020)
Health authorities around the world, including stringent ones, struggle to regulate dietary supplements. Health claims and actual effects of these products on users therefore are not adequately studied and monitored. In ...