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Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection
(University of the Western Cape, 2014)
This study focused on the synthesis of a series of novel tricycloundecane derivatives and evaluation of these compounds for neuroprotection using the fluorescent ratiometric calcium assay that indicates the ability of the ...
Polycyclic compounds as carriers for neuroactive non- steroidal anti-inflammatory drugs
(University of the Western Cape, 2017)
Recent scientific findings have highlighted the beneficial roles of polycyclic cage compounds in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Further interest into the chemistry of these compounds ...
Synthesis & biological evaluation of neuroprotective molecules with polycyclic scaffolds
(University of the Western Cape, 2017)
Among neurological disorders, many of the most devastating disorders are
neurodegenerative. Modern research associates excitotoxicity to a variety of
neuropathological conditions, suggesting that the neurodegenerative ...