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Now showing items 61-70 of 108
Ethionamide pharmacokinetics in multidrugresistant tuberculosis patients with and without HIVinfection
(University of the Western Cape, 2017)
Many studies have investigated the pharmacokinetics (PK) of anti-tuberculosis drugs
in tuberculosis patients. However, currently in South Africa, no studies have been
done on ethionamide (ETH) PK in adult MDR-TB patients ...
Preparation, characterisation and evaluation of Artemisia afra phytosomes with modified release properties
(University of the Western Cape, 2017)
Dissolution studies on various dosage forms (powder, tablets, teabags and alginate beads) of
the Artemisia afra freeze dried aqueous extract (FDAE) all exhibit a rapid release profile.
Generally, such a release profile may ...
Evaluation and comparison of current legal and regulatory framework for traditional medicines in five selected African countries: A move towards harmonization of regulation of traditional medicines in Africa.
(University of the Western Cape, 2019)
Background: In Africa, traditional medicine (TM) practice has been in existence since time
immemorial as the major source of pharmacotherapy. However, unlike orthodox medicines
TM policies and regulations are not formalised ...
A Comprehensive Study on the Global Regulatory Requirements for the submission of a Post-Approval Change, specifically a Change in Manufacturing Site
(University of the Western Cape, 2017)
Regulatory requirements for post-approval changes vary for different countries around
the world. It is a challenging and costly process for pharmaceutical companies to
manage changes to the approved regulatory dossier over ...
Discovery of anti-mycobacterial natural products from South African marine algae
(University of the Western Cape, 2019)
Tuberculosis is a communicable disease which affects millions of people around the world.
Although the case reports are declining, the eradication rate of this disease is far too slow.
Natural products have played a key ...
Review of medicine registration system in Tanzania
(University of the Western Cape, 2019)
Registration of medicines is an essential function of the national medicine regulatory system
of any country. Since the start of the medicine registration system in Tanzania in early 2000s,
no systematic review has been ...
Service learning in pharmacy: Evaluation of tuberculosis screening by pharmacy students in primary health care facilities.
(University of the Western Cape, 2019)
Background: Tuberculosis (TB) is one of the arms of the so-called quadruple burden of
disease in South Africa. One of the major impediments to TB control is failure to detect the
disease, and undiagnosed cases in the ...
Knowledge-based integration of Zimbabwean traditional medicines into the National Healthcare System: A case study of prostate cancer
(University of the Western Cape, 2017)
This study sought to identify the bottlenecks in the promotion of Zimbabwean Traditional Medicines (ZTMs) towards improving the national healthcare delivery system. The indigenous medicines lost value and recognition to ...
The availability of persons nominated for adverse drug reporting and associated challenges in Gauteng regional and district public hospitals
(University of the Western Cape, 2019)
Background and Objectives: The reporting of adverse drug reactions (ADRs) is a major public health necessity. It is estimated that only six to 10 percent of all ADRs are reported worldwide. This number is far less than the ...
Aspects of the gastrointestinal uptake and metabolism of luteolin derivatives from Artemisia afra aqueous extract (preclinical)
(University of the Western Cape, 2011)
The aim of this study was to investigate the effect the plant matrix and the structure of the flavonoid (i.e. whether aglycone or glycoside) may have on the gastrointestinal uptake and metabolism of luteolin derivatives ...