School of Pharmacy: Recent submissions
Now showing items 141-160 of 225
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Preparation, characterisation and evaluation of Artemisia afra phytosomes with modified release properties
(University of the Western Cape, 2017)Dissolution studies on various dosage forms (powder, tablets, teabags and alginate beads) of the Artemisia afra freeze dried aqueous extract (FDAE) all exhibit a rapid release profile. Generally, such a release profile may ... -
The development of a study protocol, and ethics and regulatory approval documentation, for evaluation of clinical efficacy of Sutherlandia frutescens in adult type-2 diabetics
(University of the Western Cape, 2018)The prevalence of diabetes mellitus is increasing worldwide and it is becoming a significant medical problem in low- and middle-income countries. The condition can be controlled with a lifelong commitment to blood sugar ... -
Development of a model to predict the cost of treatment of breast cancer with chemotherapy at Groote Schuur hospital
(University of the Western Cape, 2017)In South Africa, breast cancer dominates other forms of cancer affecting women in both prevalence and mortality rates according to the National Cancer Registry. The incidence and cost of breast cancer have been on the rise ... -
Novel adamantane-chloroquinolin conjugates to overcome plasmodium falciparum chloroquine resistance
(University of the Western Cape, 2017)Malaria poses devastating health and socioeconomic outcomes on global health especially among pregnant women and children below the age of 5 in endemic areas. This is exacerbated by Plasmodium falciparum resistance to ... -
Review of the effectiveness of the medicines regulatory systems in Zambia over the period 1995 to 2015
(University of the Western Cape, 2018)Due to inadequacy of data on the effectiveness of medicines regulatory systems in Zambia, this study was framed. The aim was to evaluate legislative provisions for medicines regulation under three legalregulatory- frameworks ... -
Polymer Coating of an Optimized Nano Lipid Carrier System of Harpagophytum Procumbens Extract for Oral Delivery
(University of the Western Cape, 2017)Harpagophytum procumbens is a traditional medicinal plant widely used in South African traditional healthcare to treat a range of ailments like degenerative rheumatoid arthritis, osteoarthritis, tendonitis, kidney inflammation, ... -
The use of complementary and alternative medicines in the treatment of menopausal symptoms by private healthcare patients in Pretoria, South Africa
(University of the Western Cape, 2017)BACKGROUND The use of complementary and alternative medicine (CAM) is widespread in the treatment of menopausal symptoms. While observational studies indicate that CAMs can bring some relief of symptoms, there is mixed ... -
Evaluation of the anticonvulsant activity of Elytropappus rhinocerotis (L.f) Less
(University of the Western Cape, 2016)M.Pharm thesis, Discipline of Pharmacology, School of Pharmacy, University of the Western Cape. Epilepsy is a worldwide neurological disorder which is also prevalent in South Africa. Herbal medicines, besides orthodox ... -
Design, Synthesis and Evaluation of Indole Derivatives as Multifunctional Agents against Alzheimer's disease.
(University of the Western Cape, 2017)Alzheimer's disease (AD) is an age related neurodegenerative disorder characterised by progressive memory loss and cognitive impairment. It is one of several neurodegenerative disorders occurring as a result of a process ... -
Polycyclic compounds as carriers for neuroactive non- steroidal anti-inflammatory drugs
(University of the Western Cape, 2017)Recent scientific findings have highlighted the beneficial roles of polycyclic cage compounds in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Further interest into the chemistry of these compounds ... -
Analysis on access to antiretroviral therapy for patients with different income and educational level, and the effect of treatment on quality of life after two to three months of therapy
(University of the Western cape, 2017)Access to antiretroviral therapy (ART) for HIV positive patients has brought hope and a chance to a healthier longer life with improved quality of life (QoL). In this study we explored the difference in health related ... -
A qualitative evaluation on the appropriateness of the current regulatory guidelines, on the manufacture of medicines within the radiopharmaceutical industry
(University of the Western cape, 2016)The purpose of this research thesis, is to evaluate the appropriateness of the current regulatory guidelines on the manufacture of medicinal products within the radiopharmaceutical industry. The manufacture of radiopharmaceuticals ... -
Stability of freeze-dried aqueous and other modified extracts of Leonotis leonurus
(University of the Western Cape, 2017)Leonotis leonurus, a South African indigenous medicinal plant, is frequently used in the form of a tea. However, this dosage form has many disadvantages. Consequently three L. leonurus solid extract preparations were ... -
Synthesis and evaluation of novel coumarin-donepezil derivatives as dual acting monoamine oxidase B and cholinesterase in Alzheimer's disease
(University of the Western Cape, 2016)Alzheimer's disease is a progressive neurodegenerative disease characterised by low acetylcholine (ACh) levels in the hippocampus and cortex of the brain, causing symptoms like progressive memory loss, decline in language ... -
Traditional, complementary and alternative medicine in Botswana: patients’ attitudes, knowledge and use
(University of the Western Cape, 2017)BACKGROUND: The purpose of this study was to determine use, knowledge and attitudes towards traditional, complementary and alternative medicine (TCAM) in Botswana among people who visit public health facilities. PRIMARY ... -
Paving a way to effectively regulate African traditional medicines in South Africa
(University of the Western Cape, 2017)BACKGROUND: Following the historical suppression of traditional medicines in South Africa, the government published their National Health Plan in 1994 which made provision for traditional healing as an integral and ... -
Investigation of the antidiabetic activity of Cnicusbenedictus L. in rats
(University of the Western Cape, 2016)Diabetes Mellitus, one of the major diseases affecting human population all over the world has caused significant morbidity and mortality. The management of this condition has raised the demand of safe and cost effective ... -
Pharmaceutical formulation and in-vitro testing of Dioxy MP 14 (stabilised chlorine dioxide) against mycobacteria tuberculosis
(University of the Western Cape, 2011)This study was based on Dioxy MP 14 (DMP), a brand of stabilized chlorine dioxide (SCD). The active pharmaceutical ingredient (API) of DMP is chlorine dioxide (CD) which is a potent oxidant and biocide. These properties ... -
Tacrine, trolox and tryptoline as lead compounds for the design and synthesis of multi-target drugs for Alzheimer's disease therapy
(University of the Western Cape, 2016)The cascade of neurotoxic events involved in the pathogenesis of Alzheimer's disease may explain the inefficacy of currently available treatment based on acetylcholinesterase inhibitors (AChEI - donepezil, galantamine, ... -
Cardiovascular effects, molecular docking and chemo informatics analysis of compounds isolated from leonotis leonurus
(University of the Western Cape, 2015)Leonotis leonurus (L. Leonurus) has relatively abundant diterpenes and has been used as a traditional herbal medicine for treating several ailments including influenza, muscular cramps, skin related diseases, menstrual, ...