School of Pharmacy: Recent submissions
Now showing items 121-140 of 225
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Discovery of cytotoxic natural products from South African marine sponges
(University of the Western Cape, 2018)Cancer is a major health problem worldwide and killing millions of people each year. The use of natural products as chemotherapeutic agents is well established, however, many of the currently available drugs are associated ... -
Cost-Effectiveness of selecting an Enantiopure formulation over a racemic mixture
(University of the Western Cape, 2017)The aim of this study is to provide more information in terms of the cost-effectiveness of selecting an enantiopure formulation over a racemic mixture in the context of promoting rational use of medicines. This was done ... -
The development and preparation of a quality control dossier for registration of Artemisia Afra capsules for the treatment of chronic Asthma by the South African health products regulatory authority
(University of the Western Cape, 2018)The aim of this study was to determine quality control specifications needed for a dossier and an investigator's brochure of A. afra capsules, which can be used to motivate the registration and clinical testing of A. afra ... -
Investigating the Economic Impact of Mandatory Electronic Prescribing Requirements in the United States
(University of the Western Cape, 2017)Technological advancements applied to healthcare may holistically improve the economic burden of prescription medication costs. United States legislative actions requiring utilization of electronic prescribing (e-prescribing) ... -
A Community Pharmacy perspective on the epidemiology of antimicrobial drugs in the Kuilsriver urban area
(University of the Western Cape, 2017)The epidemiology of drugs is 'defined as the manner in which drugs are used by doctors, nurses, pharmacists and patients. As such epidemiology of antimicrobial drugs is the manner in which this class of drugs is used by ... -
Pharmacoeconomic evaluation in Egypt and its role in the medicine reimbursement
(University of the Western Cape, 2018)Aim: The purpose of this research was to assess the validity of pharmacoeconomic evaluation in Egypt three years after the guideline was issued and analyse challenges and opportunities for improvement. Objectives: To conduct ... -
Innovator Medicines Versus Generic Medicine Package Inserts Safety Amendments, the Reality in South Africa
(University of the Western Cape, 2017)Availability of clinically relevant and unbiased medicine information goes a long way in promoting rational use of medicines. The package insert (PI) is one of the sources of information utilised by healthcare professionals ... -
Pharmacovigilance: An Assessment of Knowledge, Attitude and Practice of Healthcare Professionals towards Adverse Drug Reactions Reporting In Central Region of Malawi
(University of the Western Cape, 2017)AIM OF THE STUDY: To assess level of knowledge, attitude and practices of dispensing healthcare professionals towards adverse drug reactions (ADR) reporting and to determine if there are any differences in knowledge, ... -
Integrating Complementary and Alternative Medicines into Pharmacy Practice: Identifying challenges in meeting professional responsibilities and training needs
(University of the Western Cape, 2017)Community pharmacies are popular suppliers of complementary and alternative medicines (CAMs) and pharmacists encounter requests from consumers for information on them. The purpose of this study was to assess the extent to ... -
Review of the effectiveness of the medicines regulatory systems in Zambia over the period 1995 to 2015
(University of the Western Cape, 2018)Due to inadequacy of data on the effectiveness of medicines regulatory systems in Zambia, this study was framed. The aim was to evaluate legislative provisions for medicines regulation under three legalregulatory- frameworks ... -
Synthesis & biological evaluation of neuroprotective molecules with polycyclic scaffolds
(University of the Western Cape, 2017)Among neurological disorders, many of the most devastating disorders are neurodegenerative. Modern research associates excitotoxicity to a variety of neuropathological conditions, suggesting that the neurodegenerative ... -
Ethionamide pharmacokinetics in multidrugresistant tuberculosis patients with and without HIVinfection
(University of the Western Cape, 2017)Many studies have investigated the pharmacokinetics (PK) of anti-tuberculosis drugs in tuberculosis patients. However, currently in South Africa, no studies have been done on ethionamide (ETH) PK in adult MDR-TB patients ... -
Adverse pregnancy outcomes among HIV-positive pregnant women treated with efavirenz-containing antiretroviral drugs: a retrospective cohort study in the Cape Flats
(University of the Western Cape, 2017)The use of efavirenz (EFV) in the first trimester of pregnancy remains controversial. In South Africa, the use of EFV-containing antiretroviral therapy (ART) as part of a Fixed Dose Combination (FDC) during the first trimester ... -
Post-market assessment of the quality of first line regimen fixed-dose combination antiretrovirals in South Africa
(University of the Western Cape, 2017)The rapid increase in access to new antiretrovirals (ARVs) worldwide and, especially in sub-Saharan Africa, coupled with the well-documented problem of poor quality ARVs in developing countries has underscored the need for ... -
Synthesis and Physicochemical Characterisation of Poly (?-caprolactone) Nanoparticles for Delivery of Propranolol
(University of the Western Cape, 2017)Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality in both developed and developing countries; and account for around 30% of all deaths worldwide. Reports indicate that nanoparticle (NP) based drug ... -
Synthesis and Physicochemical Characterisation of Poly (?-caprolactone) Nanoparticles for Delivery of Propranolol
(University of the Western Cape, 2017)Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality in both developed and developing countries; and account for around 30% of all deaths worldwide. Reports indicate that nanoparticle (NP) based drug ... -
Microbiological parameters that influence the treatment outcomes of monodrug and multidrug-resistant tuberculosis
(University of the Western Cape, 2017)Previous studies have reported microbiological parameters such as HIV infection, resistance to anti-TB drugs such as fluoroquinolones, resistance to previous treatment with anti-TB drugsand extrapulmonary TB, causing poor ... -
A Comprehensive Study on the Global Regulatory Requirements for the submission of a Post-Approval Change, specifically a Change in Manufacturing Site
(University of the Western Cape, 2017)Regulatory requirements for post-approval changes vary for different countries around the world. It is a challenging and costly process for pharmaceutical companies to manage changes to the approved regulatory dossier over ... -
Evaluation of the effect of polyethylene glycol incorporation on the performance of poly(lactic-co-glycolic acid) nanoparticles
(University of the Western Cape, 2016)Nanoparticle drug delivery is challenged by the binding of proteins in blood which result in their rapid removal from the circulatory system. Nanoparticles engineered to delay protein binding have shown to have extended ... -
Disposal Practices for Unwanted Medicines from Households in Johannesburg
(University of the Western Cape, 2017)A mixed research method was used where quantitative research facilitated qualitative research. Three questionnaires were drafted and distributed by email to respondents in the Johannesburg area. One questionnaire was for ...