Browsing Magister Pharmaceuticae - MPharm by Issue Date
Now showing items 61-80 of 141
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Investigation of the in vitro bioavailability of luteolin from modified preparations of Artemisia afra
(University of the Western Cape, 2014)Artemisia afra (A. afra) is traditionally used for a variety of ailments and contain flavonoids e.g. luteolin which may contribute to some of its activity. It is generally administered as a tea or decoction, and such liquid ... -
A crystal engineering study of selected sulfa drugs and trimethoprim
(University of the Western Cape, 2014)The objective was to prepare new solid phases, i.e. co-crystal forms, of two sulfa antibiotic drugs (sulfamethoxazole and sulfasalazine) with trimethoprim and fourteen potential co-formers with GRAS status. Trimethoprim ... -
Prescribing practice at a tertiary level paediatric hospital in South Africa
(University of the Western Cape, 2014)The objectives of the present study were to describe the type and frequency of prescribing errors and error frequency, to determine the error frequency for different drug classes, to identify potential drug interactions ... -
Is paracetamol being prescribed and used at the correct therapeutic dose in the children population in South Africa?
(University of the Western Cape, 2014)When used at the recommended and approved therapeutic dose, paracetamol is effective. Paracetamol is available in various forms and easily accessible from general dealers and pharmacies. The liquid form is the preferred ... -
Monitoring lipid and haematological abnormalities in paediatric patients on antiretroviral therapy at a Community Health Centre in the Cape Metropole
(University of the Western Cape, 2014)South Africa faces a huge Human Immunodeficiency Virus (HIV) burden with more than 400,000 children currently on antiretroviral therapy (ART). Studies on lipid and haematological profile changes in paediatrics are of ... -
Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection
(University of the Western Cape, 2014)This study focused on the synthesis of a series of novel tricycloundecane derivatives and evaluation of these compounds for neuroprotection using the fluorescent ratiometric calcium assay that indicates the ability of the ... -
The impact an accredited third party assessor will have on the regulator’s response time
(University of the Western Cape, 2014)Globally regulators have been under scrutiny for delays in market application (MA) approvals. The main issue that surfaces in studies related to these delays is a shortage in competent reviewers. The concept of a third ... -
Novel aminoquinoline-polycyclic hybrid molecules as potential antimalarial agents
(University of the Western Cape, 2014)Plasmodium falciparum malaria continues to be a worldwide health problem, especially in developing countries in Africa and is responsible for over a million fatalities per annum. Chloroquine (CQ) is low-cost, safe and was ... -
Efavirenz pre-formulation study : selection of a cyclodextrin inclusion complex or co-crystal complex for tabletting
(University of the Western Cape, 2015)Efavirenz is a non-nucleoside reverse transcriptase inhibitor used as an anti-retroviral for the treatment of human immunodeficiency virus (HIV) type I. It is classified as a class IΙ drug under the Biopharmaceutical ... -
South African patent law : developing a balance between the rights of the patients and promoting innovation within the pharmaceutical industry
(University of the Western Cape, 2015)Background: In South Africa many patented medicines are either unavailable or carry prices that most patients cannot afford. The effects of the patents systems on patient access could greatly depending on how the burden ... -
Cardiovascular effects, molecular docking and chemo informatics analysis of compounds isolated from leonotis leonurus
(University of the Western Cape, 2015)Leonotis leonurus (L. Leonurus) has relatively abundant diterpenes and has been used as a traditional herbal medicine for treating several ailments including influenza, muscular cramps, skin related diseases, menstrual, ... -
Electronic nicotine delivery systems : approach to regulation in South Africa
(University of the Western Cape, 2015)Background: The explosion in the popularity and use of e- cigarettes over the last decade has raised concerns and incited intense discussions over their safety, efficacy and potential public health impact. Globally there ... -
A literature review on pharmacovigilance systems in off-label use of medicines
(University of the Western Cape, 2015)Problem and significance: Off-label use of medicines is not illegal; however, it can be risky and harmful, or beneficial and innovative. The main problem of this practice is the lack of systems for monitoring adverse drug ... -
Pharmacists’ perceptions of Occupational Specific Dispensation (OSD): exploratory study of career and human resource perspectives
(University of the Western Cape, 2015)Prior to 2007, South Africa’s government became concerned about the loss and inability to retain certain professionals in its employment. Health human resources were distributed in favour of the private sector and urban ... -
Adverse effects experienced by patients on first line antiretroviral drugs used at Keetmanshoop Hospital (Namibia).
(University of the Western Cape, 2015)Adverse effects are a significant factor that determine how long patients will tolerate a given antiretroviral drug regimen. They also influence treatment options, and play an important role in the much needed adherence ... -
An evaluation of western herbal complementary medicine labelling in South Africa, to determine whether the product labelling information complies with established herbal monographs and whether it meets local regulatory requirements
(University of the Western Cape, 2015)Medicines (CMs) are widely available to the South African public. However, CMs have not yet been evaluated by the Medicines Control Council (MCC). The MCC has published new guidelines for the regulation of CMs, with which ... -
Rational drug therapy monitoring in type 2 diabetes mellitus : using glycated haemoglobin as a guide for change in therapy
(University of the Western Cape, 2015)Type 2 diabetes mellitus is a progressive disease characterised by defects in insulin secretion, insulin action or both. Proper management of diabetes with appropriate drug and lifestyle interventions, guided by proper ... -
Comparison of flavonoid profile and respiratory smooth muscle relaxant effects of Artemisia afra versus Leonotis leonurus
(University of the Western Cape, 2015)Leonotis leonurus (L. leonurus) and Artemisia afra (A. afra) are two of the most commonly used medicinal plants in South Africa traditionally advocated for use in asthma. However, proper scientific studies to validate these ... -
Quality of the combined oral contraceptive pill (0.15mg levonorgestrel and 0.03mg ethinylestradiol) in the private retail pharmacies of Nyeri Town, Kenya. Results from a postmarket quality study
(University of the Western Cape, 2015)Background: The effectiveness of the combined oral contraceptive pill as a family planning method is dependent on its quality. The quality of medicines on the healthcare market is established through postmarket quality ... -
Comparison of the physicochemical characteristics and flavonoid release profiles of Sutherlandia frutescens phytosomes versus liposomes
(University of the Western Cape, 2016)Sutherlandia frutescens is a traditional plant medicine widely used in South Africa. Traditionally, the leaves of S. frutescens are mainly used as a tea, but these traditional dosage forms have several disadvantages, ...