Browsing Magister Scientiae - MSc (Pharmaceutical Chemistry) by Title
Now showing items 9-16 of 16
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Homology modelling and characterization of three-dimensional (3d) protein structures of selected variants of cyp3a4
(University of the Western Cape, 2022)The efficacy and toxicity of several drugs and prodrugs are influenced by the interindividual genetic variations in drug-metabolising enzymes. Cytochrome P450 enzymes constitute the major metabolising enzymes in humans. ... -
The implementation of the African union model law on medical products regulation and the establishment of the African medicines agency
(University of the Western Cape, 2022)Within Africa, there is insufficient access to quality, safe, efficacious and affordable medical products which can partly be attributed to lack of robust regulatory systems, a lack of competent regulatory professionals ... -
Investigating the Perception of the Influence of Pharmaceutical Marketing on Pharmacists and Doctors Dispensing and Prescribing Practices.
(University of the Western Cape, 2021)Pharmaceutical marketing via a wide range of promotional tools to doctors and pharmacists is one of the primary methods used by the pharmaceutical industry to drive product sales. Pharmaceutical representatives are the ... -
Novel adamantane-chloroquinolin conjugates to overcome plasmodium falciparum chloroquine resistance
(University of the Western Cape, 2017)Malaria poses devastating health and socioeconomic outcomes on global health especially among pregnant women and children below the age of 5 in endemic areas. This is exacerbated by Plasmodium falciparum resistance to ... -
Post-market assessment of the quality of first line regimen fixed-dose combination antiretrovirals in South Africa
(University of the Western Cape, 2017)The rapid increase in access to new antiretrovirals (ARVs) worldwide and, especially in sub-Saharan Africa, coupled with the well-documented problem of poor quality ARVs in developing countries has underscored the need for ... -
Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
(University of the Western Cape, 2020)Malaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are ... -
Synthesis and characterisation of biomimetic immunostimulatory lipid-polymer hybrid nanoparticles
(University of the Western Cape, 2022)Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis), remains a fatal infectious disease and one of the top ten leading causes of mortality, particularly in developing countries. Current drug therapy ... -
Synthesis and evaluation of 7-substituted 3-propargylamine coumarin derivatives as multifunctional monoamine oxidase and cholinesterase inhibitors for Alzheimer’s Disease treatme
(University of Western Cape, 2020)Alzheimer’s Disease (AD) is a neurodegenerative disease which results from the irreversible loss of neurons in the brain. The disease is characterized by progressive cognitive impairment with recurrent short-term memory ...