Browsing Magister Scientiae - MSc (Pharmaceutical Chemistry) by Author "Joubert, Jacques"
Now showing items 1-5 of 5
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Chalcone and curcumin hybrids of indole propargylamines as multifunctional neuroprotective agents
Musakwa, Lovetone (University of the Western Cape, 2020)Neurodegenerative disorders (NDs) are a range of chronic brain disorders that includes amongst others motor function loss. Parkinson’s disease (PD) is one of the common NDs that has an insidious onset and diagnosed when ... -
Discovery of heat shock protein90 inhibitors using structured-based virtual screening
Ngcagawule, Siyasanga (University of the Western Cape, 2023)Alzheimer's disease (AD) is the most common irreversible dementia, caused by accumulation of protein aggregates in the central nervous system, with symptoms that include memory loss and behavioural abnormalities. Cholinesterase ... -
Novel adamantane-chloroquinolin conjugates to overcome plasmodium falciparum chloroquine resistance
Yvette, Mofenge Opute (University of the Western Cape, 2017)Malaria poses devastating health and socioeconomic outcomes on global health especially among pregnant women and children below the age of 5 in endemic areas. This is exacerbated by Plasmodium falciparum resistance to ... -
Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities
Pokomi, Rostand Fankam (University of the Western Cape, 2020)Malaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are ... -
Synthesis and evaluation of 7-substituted 3-propargylamine coumarin derivatives as multifunctional monoamine oxidase and cholinesterase inhibitors for Alzheimer’s Disease treatme
Mzezewa, Sheunopa C. (University of Western Cape, 2020)Alzheimer’s Disease (AD) is a neurodegenerative disease which results from the irreversible loss of neurons in the brain. The disease is characterized by progressive cognitive impairment with recurrent short-term memory ...